Reversible mesoscopic model of protein adsorption: From equilibrium to dynamics
Soft Condensed Matter
2016-08-31 v2 Materials Science
Statistical Mechanics
Biological Physics
Biomolecules
Abstract
We present a thermodynamically consistent mesoscopic model of protein adsorption at liquid-solid interfaces. First describing the equilibrium state under varying protein concentration of the solution and binding conditions, we predict a non-trivial (non- monotonic) dependence of the experimentally observable properties of the adsorbed layer (such as the surface density and surface coverage) on these parameters. We subsequently proceed to develop a dynamical model consistent with the equilibrium description, which qualitatively reproduces known experimental phenomena and offers a promising way of studying the exchange of the adsorbed proteins by the proteins of the solution.
Cite
@article{arxiv.cond-mat/0511255,
title = {Reversible mesoscopic model of protein adsorption: From equilibrium to dynamics},
author = {Gergely J. Szollosi and Imre Derenyi and Janos Voros},
journal= {arXiv preprint arXiv:cond-mat/0511255},
year = {2016}
}