In this work, we present a method for synthetic CT (sCT) generation from zero-echo-time (ZTE) MRI aimed at structural and quantitative accuracies of the image, with a particular focus on the accurate bone density value prediction. We propose a loss function that favors a spatially sparse region in the image. We harness the ability of a multi-task network to produce correlated outputs as a framework to enable localisation of region of interest (RoI) via classification, emphasize regression of values within RoI and still retain the overall accuracy via global regression. The network is optimized by a composite loss function that combines a dedicated loss from each task. We demonstrate how the multi-task network with RoI focused loss offers an advantage over other configurations of the network to achieve higher accuracy of performance. This is relevant to sCT where failure to accurately estimate high Hounsfield Unit values of bone could lead to impaired accuracy in clinical applications. We compare the dose calculation maps from the proposed sCT and the real CT in a radiation therapy treatment planning setup.
@article{arxiv.2203.16288,
title = {Region of Interest focused MRI to Synthetic CT Translation using Regression and Classification Multi-task Network},
author = {Sandeep Kaushik and Mikael Bylund and Cristina Cozzini and Dattesh Shanbhag and Steven F Petit and Jonathan J Wyatt and Marion I Menzel and Carolin Pirkl and Bhairav Mehta and Vikas Chauhan and Kesavadas Chandrasekharan and Joakim Jonsson and Tufve Nyholm and Florian Wiesinger and Bjoern Menze},
journal= {arXiv preprint arXiv:2203.16288},
year = {2022}
}