Point Defects in Double Helix Induced by Interaction of Silver Nanoparticles with DNA
Biological Physics
2012-06-22 v1
Abstract
Interaction of DNA-silver nanoparticles (AgNPs) complexes with H3O+, Cu2+ and Cl- has been studied by spectro-photometric, spectro-fluorimetric and differential scanning micro calorimetric methods. It is shown that DNA is a catalyst in redox reactions taking place in AgNPs adsorbed on its surface. We also demonstrate that Ag+ ions that are freed after corrosion of nanoparticles show absorption into the inner part of DNA double helix, i.e. they make the so-called cross-links between complementary base pairs of DNA. The cross-links present point defects of DNA which leads in-vivo to cell death.
Cite
@article{arxiv.1206.4816,
title = {Point Defects in Double Helix Induced by Interaction of Silver Nanoparticles with DNA},
author = {Vasil G. Bregadze and Zaza G. Melikishvili and Tamar G. Giorgadze and Jamlet R. Monaselidze and Zaza V. Jaliashvili and Temur B. Khuskivadze},
journal= {arXiv preprint arXiv:1206.4816},
year = {2012}
}
Comments
7 pages, 7 figures