Phase Transition in Reconstituted Chromatin
Subcellular Processes
2015-06-26 v3
Abstract
By observing reconstituted chromatin by fluorescence microscopy (FM) and atomic force microscopy (AFM), we found that the density of nucleosomes exhibits a bimodal profile, i.e., there is a large transition between the dense and dispersed states in reconstituted chromatin. Based on an analysis of the spatial distribution of nucleosome cores, we deduced an effective thermodynamic potential as a function of the nucleosome-nucleosome distance. This enabled us to interpret the folding transition of chromatin in terms of a first-order phase transition. This mechanism for the condensation of chromatin is discussed in terms of its biological significance.
Cite
@article{arxiv.q-bio/0407011,
title = {Phase Transition in Reconstituted Chromatin},
author = {Tonau Nakai and Kohji Hizume and Shige. H. Yoshimura and Kunio Takeyasu and Kenichi Yoshikawa},
journal= {arXiv preprint arXiv:q-bio/0407011},
year = {2015}
}
Comments
16 pages, 3 figures