Nucleosome Switching
Soft Condensed Matter
2009-11-13 v1 Statistical Mechanics
Genomics
Abstract
We present a statistical-mechanical analysis of the positioning of nucleosomes along one of the chromosomes of yeast DNA as a function of the strength of the binding potential and of the chemical potential of the nucleosomes. We find a significant density of two-level nucleosome switching regions where, as a function of the chemical potential, the nucleosome distribution undergoes a "micro" first-order transition. The location of these nucleosome switches shows a strong correlation with the location of transcription-factor binding sites.
Keywords
Cite
@article{arxiv.0712.1063,
title = {Nucleosome Switching},
author = {David J. Schwab and Robijn F. Bruinsma and Joseph Rudnick and Jonathan Widom},
journal= {arXiv preprint arXiv:0712.1063},
year = {2009}
}
Comments
15 pages, 3 figures