Multi-ion conduction bands in a simple model of calcium ion channels
Biological Physics
2013-03-22 v3 Subcellular Processes
Abstract
We report self-consistent Brownian dynamics simulations of a simple electrostatic model of the selectivity filters (SF) of calcium ion channels. They reveal regular structure in the conductance and selectivity as functions of the fixed negative charge Qf at the SF. This structure consists of distinct regions of high conductance (conduction bands) M0, M1, M2 separated by regions of zero-conductance (stop-bands). Two of these conduction bands, M1 and M2, demonstrate high calcium selectivity and prominent anomalous mole fraction effects and can be identified with the L-type and RyR calcium channels.
Keywords
Cite
@article{arxiv.1209.2381,
title = {Multi-ion conduction bands in a simple model of calcium ion channels},
author = {I. Kaufman and D. G. Luchinsky and R. Tindjong and P. V. E. McClintock and R. S. Eisenberg},
journal= {arXiv preprint arXiv:1209.2381},
year = {2013}
}
Comments
14 pages, 9 figures, 38 references