We investigate the salt-dependent current modulation of bundled DNA nanostructures in a nanopore. To this end, we developed four simulation models for a 2x2 origami structure with increasing level of detail: from the mean-field level to an all-atom representation of the DNA structure. We observe a consistent pore conductivity as a function of salt concentration for all four models. However, a comparison of our data to recent experimental investigations on similar systems displays significant deviations. We discuss possible reasons for the discrepancies and propose extensions to our models for future investigations.
@article{arxiv.2011.12908,
title = {Modeling the Current Modulation of Bundled DNA Structures in Nanopores},
author = {Kai Szuttor and Florian Weik and Jean-Noël Grad and Christian Holm},
journal= {arXiv preprint arXiv:2011.12908},
year = {2021}
}