Metamorphic Proteins in light of the Anfinsen Dogma
Biomolecules
2020-06-08 v2 Populations and Evolution
Abstract
It is a common belief that metamorphic proteins challenge the Anfinsen thermodynamic hypothesis (or dogma). Here we argue against this view aims to show that metamorphic proteins not just fulfill the Anfinsen dogma but also exhibit marginal stability comparable to that seen on macromolecules and macromolecular complexes. This work contributes to our general understanding of protein classification and may spur significant progress in our effort to analyze protein evolvability.
Keywords
Cite
@article{arxiv.2005.01436,
title = {Metamorphic Proteins in light of the Anfinsen Dogma},
author = {Jorge A. Vila},
journal= {arXiv preprint arXiv:2005.01436},
year = {2020}
}