Mathematical models for order of mutation problem in myeloproliferative neoplasm: non-additivity and non-commutativity
Populations and Evolution
2023-03-20 v2 Molecular Networks
Abstract
In some patients of myeloproliferative neoplasm, two genetic mutations can be found: JAK2 V617F and TET2. When one mutation is present or not, the other mutation has different effects on regulating gene expressions. Besides, when both mutations are present, the order of occurrence might make a difference. In this paper, we build nonlinear ordinary differential equation models and Markov chain models to explain such phenomena.
Keywords
Cite
@article{arxiv.2302.07955,
title = {Mathematical models for order of mutation problem in myeloproliferative neoplasm: non-additivity and non-commutativity},
author = {Yue Wang},
journal= {arXiv preprint arXiv:2302.07955},
year = {2023}
}
Comments
Highly incomplete work that needs extensive revision