English

Haldane's formula in Cannings models: The case of moderately strong selection

Probability 2022-01-24 v6

Abstract

For a class of Cannings models we prove Haldane's formula, π(sN)2sNρ2\pi(s_N) \sim \frac{2s_N}{\rho^2}, for the fixation probability of a single beneficial mutant in the limit of large population size NN and in the regime of moderately strong selection, i.e. for sNNbs_N \sim N^{-b} and 0<b<1/20< b<1/2. Here, sNs_N is the selective advantage of an individual carrying the beneficial type, and ρ2\rho^2 is the (asymptotic) offspring variance. Our assumptions on the reproduction mechanism allow for a coupling of the beneficial allele's frequency process with slightly supercritical Galton-Watson processes in the early phase of fixation.

Keywords

Cite

@article{arxiv.2008.02225,
  title  = {Haldane's formula in Cannings models: The case of moderately strong selection},
  author = {Florin Boenkost and Adrián González Casanova and Cornelia Pokalyuk and Anton Wakolbinger},
  journal= {arXiv preprint arXiv:2008.02225},
  year   = {2022}
}

Comments

Replaced with revised version, added a discussion in Section 6