Genetic Toggle Switch Without Cooperative Binding
Molecular Networks
2009-11-13 v1
Abstract
Genetic switch systems with mutual repression of two transcription factors are studied using deterministic and stochastic methods. Numerous studies have concluded that cooperative binding is a necessary condition for the emergence of bistability in these systems. Here we show that for a range of biologically relevant conditions, a suitable combination of network structure and stochastic effects gives rise to bistability even without cooperative binding.
Keywords
Cite
@article{arxiv.q-bio/0603026,
title = {Genetic Toggle Switch Without Cooperative Binding},
author = {Azi Lipshtat and Adiel Loinger and Nathalie Q. Balaban and Ofer Biham},
journal= {arXiv preprint arXiv:q-bio/0603026},
year = {2009}
}
Comments
10 pages,4 figures