Balanced Branching in Transcription Termination
Abstract
The theory of stochastic transcription termination based on free-energy competition requires two or more reaction rates to be delicately balanced over a wide range of physical conditions. A large body of work on glasses and large molecules suggests that this should be impossible in such a large system in the absence of a new organizing principle of matter. We review the experimental literature of termination and find no evidence for such a principle but many troubling inconsistencies, most notably anomalous memory effects. These suggest that termination has a deterministic component and may conceivably be not stochastic at all. We find that a key experiment by Wilson and von Hippel allegedly refuting deterministic termination was an incorrectly analyzed regulatory effect of Mg2+ binding.
Cite
@article{arxiv.physics/0009048,
title = {Balanced Branching in Transcription Termination},
author = {K. J. Harrington and R. B. Laughlin and S. Liang},
journal= {arXiv preprint arXiv:physics/0009048},
year = {2009}
}
Comments
8 pages of RevTeX, 2 eps figures