Filovirus Glycoprotein Sequence, Structure and Virulence
Biomolecules
2014-10-07 v1
Abstract
Leading Ebola subtypes exhibit a wide mortality range, here explained at the molecular level by using fractal hydropathic scaling of amino acid sequences based on protein self-organized criticality. Specific hydrophobic features in the hydrophilic mucin-like domain suffice to account for the wide mortality range. Significance statement: Ebola virus is spreading rapidly in Africa. The connection between protein amino acid sequence and mortality is identified here.
Cite
@article{arxiv.1410.1417,
title = {Filovirus Glycoprotein Sequence, Structure and Virulence},
author = {J. C. Phillips},
journal= {arXiv preprint arXiv:1410.1417},
year = {2014}
}