Distribution of the second virial coefficients of globular proteins
Abstract
George and Wilson [Acta. Cryst. D 50, 361 (1994)] looked at the distribution of values of the second virial coefficient of globular proteins, under the conditions at which they crystallise. They found the values to lie within a fairly narrow range. We have defined a simple model of a generic globular protein. We then generate a set of proteins by picking values for the parameters of the model from a probability distribution. At fixed solubility, this set of proteins is found to have values of the second virial coefficient that fall within a fairly narrow range. The shape of the probability distribution of the second virial coefficient is Gaussian because the second virial coefficient is a sum of contributions from different patches on the protein surface.
Keywords
Cite
@article{arxiv.cond-mat/0207293,
title = {Distribution of the second virial coefficients of globular proteins},
author = {Richard P. Sear},
journal= {arXiv preprint arXiv:cond-mat/0207293},
year = {2009}
}
Comments
5 pages, including 3 figures