Cooperativity of Protein Folding and the Random-Field Ising Model
Condensed Matter
2007-05-23 v1 q-bio
Abstract
The relation between cooperativity of protein folding and the Random-Field Ising Model (RFIM) is established. Generalization of the Imry-Ma argument predicts cooperative folding transition for small heterogeneity of the interactions stabilizing the native structure. Monte Carlo simulation of a lattice model shows that starting from some finite heterogeneity folding transition is not cooperative and involves formation of domains.
Keywords
Cite
@article{arxiv.cond-mat/9606136,
title = {Cooperativity of Protein Folding and the Random-Field Ising Model},
author = {A. M. Gutin and V. I. Abkevich and E. I. Shakhnovich},
journal= {arXiv preprint arXiv:cond-mat/9606136},
year = {2007}
}