Despite the advantages of using biodegradable metals in implant design, their uncontrolled degradation and release remain a challenge in practical applications. A validated computational model of the degradation process can facilitate the tuning of implant biodegradation by changing design properties. In this study, a physicochemical model was developed by deriving a mathematical description of the chemistry of magnesium biodegradation and implementing it in a 3D computational model. The model parameters were calibrated using the experimental data of hydrogen evolution by performing a Bayesian optimization routine. The model was validated by comparing the predicted change of pH in saline and buffered solutions with the experimentally obtained values from corrosion tests, showing maximum 5% of difference, demonstrating the model's validity to be used for practical cases.
@article{arxiv.2102.10064,
title = {Computational modeling of degradation process of biodegradable magnesium biomaterials},
author = {Mojtaba Barzegari and Di Mei and Sviatlana V. Lamaka and Liesbet Geris},
journal= {arXiv preprint arXiv:2102.10064},
year = {2021}
}