Complexation of DNA with Cationic Surfactant
Condensed Matter
2019-08-17 v1 q-bio
Abstract
Transfection of an anionic polynucleotide through a negatively charged membrane is an important problem in genetic engineering. The direct association of cationic surfactant to DNA decreases the effective negative charge of the nucleic acid, allowing the DNA-surfactant complex to approach a negatively charged membrane. The paper develops a theory for solutions composed of polyelectrolyte, salt, and ionic surfactant. The theoretical predictions are compared with the experimental measurements.
Keywords
Cite
@article{arxiv.cond-mat/9904447,
title = {Complexation of DNA with Cationic Surfactant},
author = {P. S. Kuhn and Marcia C. Barbosa and Y. Levin},
journal= {arXiv preprint arXiv:cond-mat/9904447},
year = {2019}
}
Comments
9 pages, 3 figures