Characterization of the Endemic Equilibrium and Response to Mutant Injection in a Multi-strain Disease Model
Populations and Evolution
2014-04-09 v1
Abstract
Starting from common assumptions, we build a rate equation model for multi-strain disease dynamics in terms of immune repertoire classes. We then move to a strain-level description where a low-order closure reminiscent of a pair approximation can be applied. We characterize the endemic equilibrium of the ensuing model in the absence of mutation and discuss the presence of degeneracy regarding the prevalence of the different strains. Finally we study the behavior of the system under the injection of mutant strains.
Keywords
Cite
@article{arxiv.1404.2147,
title = {Characterization of the Endemic Equilibrium and Response to Mutant Injection in a Multi-strain Disease Model},
author = {Tomás Aquino and Diogo Bolster and Ana Nunes},
journal= {arXiv preprint arXiv:1404.2147},
year = {2014}
}
Comments
20 pages, 5 figures