Bismuth Ferrite (BFO) nanoparticles (BFO-NP) display interesting optical (nonlinear response) and magnetic properties which make them amenable for bio-oriented applications as intra- and extra membrane contrast agents. Due to the relatively recent availability of this material in well dispersed nanometric form, its biocompatibility was not known to date. In this study, we present a thorough assessment of the effects of in vitro exposure of human adenocarcinoma (A549), lung squamous carcinoma (NCI-H520), and acute monocytic leukemia (THP-1) cell lines to uncoated and poly(ethylene glycol)-coated BFO-NP in the form of cytotoxicity, haemolytic response and biocompatibility. Our results support the attractiveness of the functional-BFO towards biomedical applications focused on advanced diagnostic imaging.
@article{arxiv.1410.2068,
title = {Cellular Uptake and Biocompatibility of Bismuth Ferrite Harmonic Advanced Nanoparticles},
author = {Davide Staedler and Solène Passemard and Thibaud Magouroux and Andrii Rogov and Ciaran Manus Maguire and Bashir M. Mohamed and Sebastian Schwung and Daniel Rytz and Thomas Jüstel and Stéphanie Hwu and Yannick Mugnier and Ronan Le Dantec and Yuri Volkov and Sandrine Gerber-Lemaire and Adriele Prina-Melloc and Luigi Bonacina and Jean-Pierre Wolf},
journal= {arXiv preprint arXiv:1410.2068},
year = {2014}
}
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Abstract Word Count: 109 Complete Word Count (body text and figure legends) : 4886 Number of Figures: 6 Number of Tables: 0 Number of reference: 45