Cellular Griffiths-like phase
Abstract
Protein compartmentalization in the frame of a liquid-liquid phase separation is a key mechanism to optimize spatiotemporal control of biological systems. Such a compartmentalization process reduces the intrinsic noise in protein concentration due to stochasticity in gene expression. Employing Flory-Huggins solution theory, Avramov/Casalini's model, and the Gr\"uneisen parameter, we unprecedentedly propose a cellular Griffiths-like phase (CGLP), which can impact its functionality and self-organization. The here-proposed CGLP is key ranging from the understanding of primary organisms' evolution to the treatment of diseases. Our findings pave the way for an alternative Biophysics approach to investigate coacervation processes.
Cite
@article{arxiv.2409.17292,
title = {Cellular Griffiths-like phase},
author = {Lucas Squillante and Isys F. Mello and Luciano S. Ricco and Marcos F. Minicucci and Aniekan Magnus Ukpong and Antonio C. Seridonio and Roberto E. Lagos-Monaco and Mariano de Souza},
journal= {arXiv preprint arXiv:2409.17292},
year = {2024}
}
Comments
13 pages, 2 figures, suppl. material upon request