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Related papers: Cellular Griffiths-like phase

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Phagocytosis is the process of engulfment and internalization of comparatively large particles by the cell, that plays a central role in the functioning of our immune system. We study the process of phagocytosis by considering a simplified…

Soft Condensed Matter · Physics 2022-01-05 Raj Kumar Sadhu , Sarah R Barger , Samo Penič , Aleš Iglič , Mira Krendel , Nils C Gauthier , Nir S Gov

Understanding the (de)mixing behavior of multicomponent lipid bilayers is an important step towards unraveling the nature of spatial composition heterogeneities in cellular membranes and their role in biological function. We use…

Soft Condensed Matter · Physics 2018-05-17 Shushan He , Lutz Maibaum

Phase separation has emerged as an essential concept for the spatial organization inside biological cells. However, despite the clear relevance to virtually all physiological functions, we understand surprisingly little about what phases…

Biological Physics · Physics 2022-08-10 David Zwicker , Liedewij Laan

Membrane phase-separation is a mechanism that biological membranes often use to locally concentrate specific lipid species in order to organize diverse membrane processes. Phase separation has also been explored as a tool for the design of…

Computational Physics · Physics 2020-06-26 Alexander Zhiliakov , Yifei Wang , Annalisa Quaini , Maxim Olshanskii , Sheereen Majd

Cell membranes phase separate into ordered ${\rm L_o}$ and disordered ${\rm L_d}$ domains depending on their compositions. This membrane compartmentalization is heterogeneous and regulates the localization of specific proteins related to…

Soft Condensed Matter · Physics 2023-08-11 Ken Sakamoto , Takuma Akimoto , Mayu Muramatsu , Mark S. P. Sansom , Ralf Metzler , Eiji Yamamoto

The Flory-Huggins theory is a well-established lattice model that is commonly used to study the mixing of distinct chemical species. It can successfully predict phase separation phenomena in blends of incompatible materials. However, it is…

Materials Science · Physics 2025-12-19 Maxime Siber , Olivier J. J. Ronsin , Jens Harting

In view of the notorious complexity of protein--protein interactions, simplified models of proteins treated as patchy particles offer a promising strategy to obtain insight into the mechanism of crystallization. Here we report…

Soft Condensed Matter · Physics 2019-10-16 Jens Glaser , Sharon C. Glotzer

Differences in activities in colloidal particles are sufficient to drive phase separation between active and passive (or less active) particles, even if they have only excluded volume interactions. In this paper, we study the phase…

Soft Condensed Matter · Physics 2020-05-27 Efe Ilker , Jean-François Joanny

Liquid-liquid phase separation plays a major role in the formation and maintenance of various membrane-less subcellular structures in the cytoplasm and nucleus of cells. Biological condensates contain enhanced concentrations of proteins and…

Soft Condensed Matter · Physics 2023-10-03 Paul C Bressloff

Biologically functional liquid-liquid phase separation of intrinsically disordered proteins (IDPs) is driven by interactions encoded by their amino acid sequences. Little is currently known about the molecular recognition mechanisms for…

Biomolecules · Quantitative Biology 2017-11-15 Yi-Hsuan Lin , Jacob P. Brady , Julie D. Forman-Kay , Hue Sun Chan

Hallmarks of criticality, such as power-laws and scale invariance, have been empirically found in cortical networks and it has been conjectured that operating at criticality entails functional advantages, such as optimal computational…

Disordered Systems and Neural Networks · Physics 2014-11-13 Paolo Moretti , Miguel A. Muñoz

Active liquid-liquid phase separation (LLPS) in a confining environment is believed to play an important role in cell biology. Recently, it was shown that when active noise at the microscopic level is included in the classical theory of…

Soft Condensed Matter · Physics 2024-08-16 Chen Lin , Robijn Bruinsma

The Griffiths phase has been proposed to induce a stretched critical regime that facilitates self-organizing of brain networks for optimal function. This phase stems from the intrinsic structural heterogeneity of brain networks, such as the…

Disordered Systems and Neural Networks · Physics 2017-03-15 Shanshan Li

We study Gibbs partition models, also known as composition schemes. Our main results comprehensively describe their phase diagram, including a phase transition from the convergent case described in Stufler (2018, Random Structures \&…

Probability · Mathematics 2022-11-22 Benedikt Stufler

Soft condensed matter structures often challenge us with complex many-body phenomena governed by collective modes spanning wide spatial and temporal domains. In order to successfully tackle such problems mesoscopic coarse-grained (CG)…

Soft Condensed Matter · Physics 2023-07-12 Vlad P Sokhan , Michael A Seaton , Ilian T Todorov

Liquid-liquid phase separation has emerged as a fundamental mechanism underlying intracellular organization, with evidence for it being reported in numerous different systems. However, there is a growing concern regarding the lack of…

Soft Condensed Matter · Physics 2022-12-09 Mrityunjay Kothari , Tal Cohen

We explore the coexistence region in the vicinity of the Mott critical end point employing a compressible cell spin-$1/2$ Ising-like model. We analyze the case for the spin-liquid candidate $\kappa$-(BEDT-TTF)$_2$Cu$_2$(CN)$_3$, where close…

Strongly Correlated Electrons · Physics 2021-02-03 Isys F. Mello , Lucas Squillante , Gabriel O. Gomes , Antonio C. Seridonio , M. de Souza

Investigation of protein self-assembly processes is important for the understanding of the growth processes of functional proteins as well as disease-causing amyloids. Inside cells, intrinsic molecular fluctuations are so high that they…

Biological Physics · Physics 2021-02-03 John Bridstrup , John S Schreck , Jesse L Jorgenson , Jian-Min Yuan

Phase separation and coarsening is a phenomenon commonly seen in binary physical and chemical systems that occur in nature. Often times, thermal fluctuations, modeled as stochastic noise, are present in the system and the phase segregation…

Soft Condensed Matter · Physics 2017-04-19 Prerna Gera , David Salac

We introduce a reversible Markovian coagulation-fragmentation process on the set of partitions of $\{1,\ldots,L\}$ into disjoint intervals. Each interval can either split or merge with one of its two neighbors. The invariant measure can be…

Probability · Mathematics 2013-11-27 Cedric Bernardin , Fabio Lucio Toninelli
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