Biological implications of $\mathfrak{so}(2,1)$ symmetry in exact solutions for a self-repressing gene
Molecular Networks
2019-07-12 v2
Abstract
We chemically characterize the symmetries underlying the exact solutions of a stochastic negatively self-regulating gene. The breaking of symmetry at low molecular number causes three effects. Two branches of the solution exist, having high and low switching rates, such that the low switching rate branch approaches deterministic behavior and the high switching rate branch exhibits sub-Fano behavior. Average protein number differs from the deterministically expected value. Bimodal probability distributions appear as the protein number becomes a readout of the ON/OFF state of the gene.
Keywords
Cite
@article{arxiv.1707.04365,
title = {Biological implications of $\mathfrak{so}(2,1)$ symmetry in exact solutions for a self-repressing gene},
author = {Alexandre F. Ramos and John Reinitz},
journal= {arXiv preprint arXiv:1707.04365},
year = {2019}
}