Analytical study of the effect of recombination on evolution via DNA shuffling
Biological Physics
2009-11-10 v1 Statistical Mechanics
Populations and Evolution
Abstract
We investigate a multi-locus evolutionary model which is based on the DNA shuffling protocol widely applied in \textit{in vitro} directed evolution. This model incorporates selection, recombination and point mutations. The simplicity of the model allows us to obtain a full analytical treatment of both its dynamical and equilibrium properties, for the case of an infinite population. We also briefly discuss finite population size corrections.
Cite
@article{arxiv.physics/0303120,
title = {Analytical study of the effect of recombination on evolution via DNA shuffling},
author = {Weiqun Peng and Herbert Levine and Terence Hwa and David A. Kessler},
journal= {arXiv preprint arXiv:physics/0303120},
year = {2009}
}