We propose an aqueous functionalized molybdenum disulfide nanoribbon suspended over a solid electrode as the first capacitive displacement sensor aimed at determining the DNA sequence. The detectable sequencing events arise from the combination of Watson-Crick base-pairing, one of nature's most basic lock-and-key-binding mechanisms, with the ability of appropriately sized atomically thin membranes to flex substantially in response to sub-nanonewton forces. We employ carefully designed numerical simulations and theoretical estimates to demonstrate excellent (79 % to 86 %) raw target detection accuracy at ~70 million bases per second and electrical measurability of the detected events. In addition, we demonstrate reliable detection of repeated DNA motifs. Finally, we argue that the use of a nanoscale opening (nanopore) is not requisite for the operation of the proposed sensor and present a simplified sensor geometry without the nanopore as part of the sensing element. Our results therefore potentially suggest a realistic, inherently base-specific, high-throughput electronic DNA sequencing device as a cost-effective de-novo alternative to the existing methods.
@article{arxiv.1606.07123,
title = {A MoS2-based capacitive displacement sensor for DNA sequencing},
author = {A. Smolyanitsky and B. I. Yakobson and T. A. Wassenaar and E. Paulechka and K. Kroenlein},
journal= {arXiv preprint arXiv:1606.07123},
year = {2016}
}