Towards Increased Reliability, Transparency and Accessibility in Crosslinking Mass Spectrometry
Abstract
Crosslinking mass spectrometry (Crosslinking MS) has substantially matured as a method over the last two decades through parallel development in multiple labs, demonstrating its applicability for protein structure determination, conformation analysis and mapping protein interactions in complex mixtures. Crosslinking MS has become a much-appreciated and routinely applied tool especially in structural biology. Therefore, it is timely that the community commits to the development of methodological and reporting standards. This white paper builds on an open process comprising a number of events at community conferences since 2015 and identifies aspects of Crosslinking MS for which guidelines should be developed as part of a Crosslinking MS standards initiative.
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Cite
@article{arxiv.2007.00383,
title = {Towards Increased Reliability, Transparency and Accessibility in Crosslinking Mass Spectrometry},
author = {Alexander Leitner and Alexandre M. J. J. Bonvin and Christoph H. Borchers and Robert J. Chalkley and Julia Chamot-Rooke and Colin W. Combe and Jürgen Cox and Meng-Qiu Dong and Lutz Fischer and Michael Götze and Fabio C. Gozzo and Albert J. R. Heck and Michael R. Hoopmann and Lan Huang and Yasushi Ishihama and Andrew R. Jones and Nir Kalisman and Oliver Kohlbacher and Karl Mechtler and Robert L. Moritz and Eugen Netz and Petr Novak and Evgeniy Petrotchenko and Andrej Sali and Richard A. Scheltema and Carla Schmidt and David Schriemer and Andrea Sinz and Frank Sobott and Florian Stengel and Konstantinos Thalassinos and Henning Urlaub and Rosa Viner and Juan A. Vizcaino and Marc R. Wilkins and Juri Rappsilber},
journal= {arXiv preprint arXiv:2007.00383},
year = {2020}
}
Comments
26 pages, 1 figure