English

Topological data analysis of C. elegans locomotion and behavior

Algebraic Topology 2021-07-23 v3 Quantitative Methods

Abstract

We apply topological data analysis to the behavior of C. elegans, a widely-studied model organism in biology. In particular, we use topology to produce a quantitative summary of complex behavior which may be applied to high-throughput data. Our methods allow us to distinguish and classify videos from various environmental conditions and we analyze the trade-off between accuracy and interpretability. Furthermore, we present a novel technique for visualizing the outputs of our analysis in terms of the input. Specifically, we use representative cycles of persistent homology to produce synthetic videos of stereotypical behaviors.

Keywords

Cite

@article{arxiv.2102.09380,
  title  = {Topological data analysis of C. elegans locomotion and behavior},
  author = {Ashleigh Thomas and Kathleen Bates and Alex Elchesen and Iryna Hartsock and Hang Lu and Peter Bubenik},
  journal= {arXiv preprint arXiv:2102.09380},
  year   = {2021}
}

Comments

27 pages, 15 figures/tables

R2 v1 2026-06-23T23:17:26.112Z