Topological data analysis of C. elegans locomotion and behavior
Algebraic Topology
2021-07-23 v3 Quantitative Methods
Abstract
We apply topological data analysis to the behavior of C. elegans, a widely-studied model organism in biology. In particular, we use topology to produce a quantitative summary of complex behavior which may be applied to high-throughput data. Our methods allow us to distinguish and classify videos from various environmental conditions and we analyze the trade-off between accuracy and interpretability. Furthermore, we present a novel technique for visualizing the outputs of our analysis in terms of the input. Specifically, we use representative cycles of persistent homology to produce synthetic videos of stereotypical behaviors.
Cite
@article{arxiv.2102.09380,
title = {Topological data analysis of C. elegans locomotion and behavior},
author = {Ashleigh Thomas and Kathleen Bates and Alex Elchesen and Iryna Hartsock and Hang Lu and Peter Bubenik},
journal= {arXiv preprint arXiv:2102.09380},
year = {2021}
}
Comments
27 pages, 15 figures/tables