English

Spatially explicit non-Mendelian diploid model

Probability 2009-10-22 v1

Abstract

We introduce a spatially explicit model for the competition between type aa and type bb alleles. Each vertex of the dd-dimensional integer lattice is occupied by a diploid individual, which is in one of three possible states or genotypes: aaaa, abab or bbbb. We are interested in the long-term behavior of the gene frequencies when Mendel's law of segregation does not hold. This results in a voter type model depending on four parameters; each of these parameters measures the strength of competition between genes during meiosis. We prove that with or without a spatial structure, type aa and type bb alleles coexist at equilibrium when homozygotes are poor competitors. The inclusion of a spatial structure, however, reduces the parameter region where coexistence occurs.

Cite

@article{arxiv.0910.4009,
  title  = {Spatially explicit non-Mendelian diploid model},
  author = {N. Lanchier and C. Neuhauser},
  journal= {arXiv preprint arXiv:0910.4009},
  year   = {2009}
}

Comments

Published in at http://dx.doi.org/10.1214/09-AAP598 the Annals of Applied Probability (http://www.imstat.org/aap/) by the Institute of Mathematical Statistics (http://www.imstat.org)

R2 v1 2026-06-21T14:01:18.187Z