Light-ion microbeams provide a unique opportunity to irradiate biological samples at the cellular level and to investigate radiobiological effects at low doses of high LET ionising radiation. Since 1998 a single-ion irradiation facility has been developed on the focused horizontal microbeam line of the CENBG 3.5 MV Van de Graaff accelerator. This setup delivers in air single protons and alpha particles of a few MeV onto cultured cells, with a spatial resolution of a few microns, allowing subcellular targeting. In this paper, we present results from the use of the GEANT4 toolkit to simulate cellular irradiation with the CENBG microbeam line, from the entrance to the microprobe up to the cellular medium.
@article{arxiv.physics/0310130,
title = {Simulation of cellular irradiation with the CENBG microbeam line using GEANT4},
author = {S. Incerti and Ph. Barberet and R. Villeneuve and P. Aguer and E. Gontier and C. Michelet-Habchi and Ph. Moretto and D. T. Nguyen and T. Pouthier and R. W. Smith},
journal= {arXiv preprint arXiv:physics/0310130},
year = {2009}
}
Comments
6 pages, 8 figures, presented at the 2003 IEEE-NSS conference, Portland, OR, USA, October 20-24, 2003