Markovianness and Conditional Independence in Annotated Bacterial DNA
Quantitative Methods
2013-11-19 v1 Probability
Genomics
Applications
Abstract
We explore the probabilistic structure of DNA in a number of bacterial genomes and conclude that a form of Markovianness is present at the boundaries between coding and non-coding regions, that is, the sequence of START and STOP codons annotated for the bacterial genome. This sequence is shown to satisfy a conditional independence property which allows its governing Markov chain to be uniquely identified from the abundances of START and STOP codons. Furthermore, the annotated sequence is shown to comply with Chargaff's second parity rule at the codon level.
Cite
@article{arxiv.1311.4411,
title = {Markovianness and Conditional Independence in Annotated Bacterial DNA},
author = {Andrew Hart and Servet Martínez},
journal= {arXiv preprint arXiv:1311.4411},
year = {2013}
}
Comments
23 pages (including a 5 page appendix), 1 figure, 9 tables