Inferring genotyping error rates from genotyped trios
Quantitative Methods
2011-09-08 v1
Abstract
Genotyping errors are known to influence the power of both family-based and case-control studies in the genetics of complex disease. Estimating genotyping error rate in a given dataset can be complex, but when family information is available error rates can be inferred from the patterns of Mendelian inheritance between parents and offspring. I introduce a novel likelihood-based method for calculating error rates from family data, given known allele frequencies. I apply this to an example dataset, demonstrating a low genotyping error rate in genotyping data from a personal genomics company.
Cite
@article{arxiv.1109.1462,
title = {Inferring genotyping error rates from genotyped trios},
author = {Luke Jostins},
journal= {arXiv preprint arXiv:1109.1462},
year = {2011}
}