Group Sequential Clinical Trial Designs for Normally Distributed Outcome Variables
Computation
2017-11-29 v2
Abstract
In a group sequential clinical trial, accumulated data are analysed at numerous time-points in order to allow early decisions about a hypothesis of interest. These designs have historically been recommended for their ethical, administrative and economic benefits. In this work, we discuss a collection of new Stata commands for computing the stopping boundaries and required group size of various classical group sequential designs, assuming a normally distributed outcome variable. Following this, we demonstrate how the performance of several designs can be compared graphically.
Cite
@article{arxiv.1710.03127,
title = {Group Sequential Clinical Trial Designs for Normally Distributed Outcome Variables},
author = {Michael Grayling and James Wason and Adrian Mander},
journal= {arXiv preprint arXiv:1710.03127},
year = {2017}
}