Forbidding Exactly One Hamming Distance

Addressing questions raised in recent papers, we study the $r$-distance graph $H_r(n)$ on the Boolean cube $\{0,1\}^n$, where two vertices are adjacent if their Hamming distance is exactly $r$. For fixed integers $s \ge 2$ and even $r \ge 2$, we determine the asymptotic order of the $s$-independence number $\alpha_s(H_r(n))$, showing that $$\alpha_s\left(H_r(n)\right)=\Theta\left(\frac{2^n}{n^{r/2}}\right).$$ The upper bound is derived via a reduction to extremal problems for sunflower-free set systems, while the lower bound is obtained using algebraic constructions based on BCH codes and constant-weight codes.