Evolution of the Ubiquitin-Activating Enzyme Uba1 (E1)
Other Quantitative Biology
2017-05-24 v1
Abstract
Ubiquitin tags diseased proteins and initiates an enzyme conjugation cascade, which has three stages. The first-stage enzyme Uba1 (E1) has evolved only modestly from slime mold to humans, and is > 14 times larger than Ub. Here we use critical point thermodynamic scaling theory to connect Uba1 (E1) evolution from yeast and slime mold to fruit flies and humans to subtle changes in its amino acid sequences.
Cite
@article{arxiv.1702.06950,
title = {Evolution of the Ubiquitin-Activating Enzyme Uba1 (E1)},
author = {Douglas C. Allan and J. C. Phillips},
journal= {arXiv preprint arXiv:1702.06950},
year = {2017}
}
Comments
12 pages, 6 figures