Equal Marginal Power for Co-Primary Endpoints
Methodology
2026-02-23 v1
Abstract
The choice of sample size in the context of co-primary endpoints for a randomised trial is discussed. Current guidance can leave endpoints with unequal marginal power. A method is provided to achieve equal marginal power by using the flexibility provided in multiple testing procedures. A comparison is made to several choices of rule to determine the sample size, in terms of the study design and its operating characteristics.
Cite
@article{arxiv.2602.18161,
title = {Equal Marginal Power for Co-Primary Endpoints},
author = {Simon Bond},
journal= {arXiv preprint arXiv:2602.18161},
year = {2026}
}
Comments
10 pages, 3 figures