Dynamic compensation and homeostasis: a feedback control perspective
Abstract
"Dynamic compensation" is a robustness property where a perturbed biological circuit maintains a suitable output [Karin O., Swisa A., Glaser B., Dor Y., Alon U. (2016). Mol. Syst. Biol., 12: 886]. In spite of several attempts, no fully convincing analysis seems now to be on hand. This communication suggests an explanation via "model-free control" and the corresponding "intelligent" controllers [Fliess M., Join C. (2013). Int. J. Contr., 86, 2228-2252], which are already successfully applied in many concrete situations. As a byproduct this setting provides also a slightly different presentation of homeostasis, or "exact adaptation," where the working conditions are assumed to be "mild." Several convincing, but academic, computer simulations are provided and discussed.
Keywords
Cite
@article{arxiv.1801.04959,
title = {Dynamic compensation and homeostasis: a feedback control perspective},
author = {Michel Fliess and Cédric Join},
journal= {arXiv preprint arXiv:1801.04959},
year = {2018}
}
Comments
Research Report, Ecole polytechnique, Palaiseau, France