The limits of TDF (time, dose, and fractionation) and linear quadratic models have been known for a long time. Medical physicists and physicians are required to provide fast and reliable interpretations regarding the delivered doses or any future prescriptions relating to treatment changes. We therefore propose a calculation interface under the GNU license to be used for equivalent doses, biological doses, and normal tumor complication probability (Lyman model). The methodology used draws from several sources: the linear-quadratic-linear model of Astrahan, the repopulation effects of Dale, and the prediction of multi-fractionated treatments of Thames. The results are obtained from an algorithm that minimizes an ad-hoc cost function, and then compared to the equivalent dose computed using standard calculators in seven French radiotherapy centers.
Cite
@article{arxiv.1308.5906,
title = {Biological effects and equivalent doses in radiotherapy: a software solution},
author = {Cyril Voyant and Daniel Julian and Rudy Roustit and Katia Biffi and Celine Lantieri Marcovici},
journal= {arXiv preprint arXiv:1308.5906},
year = {2013}
}