Sensitive and reliable methylation assay is important for oncogentic studies and clinical applications. Here, a new methylation assay was developed by the use of adapter-dependent adapter in library preparation. This new assay avoids the use of bisulfite and provides a simple and highly sensitive scanning of methylation spectra of circulating free DNA and genomic DNA.
@article{arxiv.2410.04137,
title = {Adapter-dependent Adapter Methylation Assay},
author = {Jia Zhang and Peng Qi and Li Xiao and Mengxi Yuan and Jun Chuan and Yaling Zeng and Li-mei Lin and Yue Gu and Yan Zhang and Duan-fang Liao and Kai Li},
journal= {arXiv preprint arXiv:2410.04137},
year = {2024}
}