A stochastic modeling framework for single cell migration: coupling contractility and focal adhesions
Abstract
The interaction of the actin cytoskeleton with cell-substrate adhesions is necessary for cell migration. While the trajectories of motile cells have a stochastic character, investigations of cell motility mechanisms rarely elaborate on the origins of the observed randomness. Here, guided by a few fundamental attributes of cell motility, we construct a minimal stochastic cell migration model from ground-up. The resulting model couples a deterministic actomyosin contractility mechanism with stochastic cell-substrate adhesion kinetics, and yields a well-defined piecewise deterministic process. Numerical simulations reproduce several experimentally observed results, including anomalous diffusion, tactic migration, and contact guidance. This work provides a basis for the development of cell-cell collision and population migration models.
Cite
@article{arxiv.1810.11435,
title = {A stochastic modeling framework for single cell migration: coupling contractility and focal adhesions},
author = {Aydar Uatay},
journal= {arXiv preprint arXiv:1810.11435},
year = {2019}
}