A double-exponential lower bound for $r_4(5,n)$

The Ramsey number $r_k(s,n)$ is the smallest integer $N$ such that every $N$-vertex $k$-graph contains either a copy of $K_s^{(k)}$ or an independent set of size $n$. We prove that $r_4(5,n)\ge 2^{2^{cn^{1/7}}}$, where $c>0$ is an absolute constant. As a consequence, we determine the tower growth rate of $r_k(k+1,n)$, which completely solves the problem of establishing the tower growth rate for all classical off-diagonal hypergraph Ramsey numbers, first posed by Erd\H{o}s and Hajnal in 1972.