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The last decade has witnessed a surge of theoretical and computational models to describe the dynamics of complex gene regulatory networks, and how these interactions can give rise to multistable and heterogeneous cell populations. As the…

Molecular Networks · Quantitative Biology 2023-06-28 Federico Bocci , Dongya Jia , Qing Nie , Mohit Kumar Jolly , Jose Onuchic

Neural network design has utilized flexible nonlinear processes which can mimic biological systems, but has suffered from a lack of traceability in the resulting network. Graphical probabilistic models ground network design in probabilistic…

Machine Learning · Computer Science 2015-06-19 Kenric P. Nelson , Madalina Barbu , Brian J. Scannell

Biomolecular networks have already found great utility in characterizing complex biological systems arising from pair-wise interactions amongst biomolecules. Here, we review how graph theoretical approaches can be applied not only for a…

Molecular Networks · Quantitative Biology 2018-12-03 Heeralal Janwa , Steven E. Massey , Julian Velev , Bud Mishra

Dynamic networks, a.k.a. graph streams, consist of a set of vertices and a collection of timestamped interaction events (i.e., temporal edges) between vertices. Temporal motifs are defined as classes of (small) isomorphic induced subgraphs…

Methodology · Statistics 2022-02-23 Xiaojing Zhu , Eric D. Kolaczyk

Accurately determining and classifying the structure of complex networks is the focus of much current research. One class of network of particular interest are metabolic pathways, which have previously been studied from a graph theoretical…

Mathematical Physics · Physics 2012-10-10 Henry Dorrian , Kieran Smallbone , Jon borresen

Despite recent molecular technique improvements, biological knowledge remains incomplete. Reasoning on living systems hence implies to integrate heterogeneous and partial informations. Although current investigations successfully focus on…

Quantitative Methods · Quantitative Biology 2009-09-29 Jérémie Bourdon , Damien Eveillard , Samuel Gabillard , Theo Merle

Many real life networks present an average path length logarithmic with the number of nodes and a degree distribution which follows a power law. Often these networks have also a modular and self-similar structure and, in some cases -…

Physics and Society · Physics 2010-02-17 Alicia Miralles , Francesc Comellas , Lichao Chen , Zhongzhi Zhang

Networks effectively capture interactions among components of complex systems, and have thus become a mainstay in many scientific disciplines. Growing evidence, especially from biology, suggest that networks undergo changes over time, and…

Methodology · Statistics 2020-03-10 Ali Shojaie

Sequences of correlated binary patterns can represent many time-series data including text, movies, and biological signals. These patterns may be described by weighted combinations of a few dominant structures that underpin specific…

Machine Learning · Statistics 2019-03-29 Jimmy Gaudreault , Arunabh Saxena , Hideaki Shimazaki

Numerous social, medical, engineering and biological challenges can be framed as graph-based learning tasks. Here, we propose a new feature based approach to network classification. We show how dynamics on a network can be useful to reveal…

Machine Learning · Statistics 2017-06-01 Leonardo Gutierrez Gomez , Benjamin Chiem , Jean-Charles Delvenne

Online social network services provide a platform for human social interactions. Nowadays, many kinds of online interactions generate large-scale social network data. Network analysis helps to mine knowledge and pattern from the…

Social and Information Networks · Computer Science 2021-02-19 Andry Alamsyah , Yahya Peranginangin , Intan Muchtadi-Alamsyah , Budi Rahardjo , Kuspriyanto

With the advance of efficient analytical methods for sensitivity analysis ofprobabilistic networks, the interest in the sensitivities revealed by real-life networks is rekindled. As the amount of data resulting from a sensitivity analysis…

Artificial Intelligence · Computer Science 2013-01-14 Linda C. van der Gaag , Silja Renooij

In order to improve the resilience of computer infrastructure against cyber attacks and finding ways to mitigate their impact we need to understand their structure and dynamics. Here we propose a novel network-based influence spreading…

Social and Information Networks · Computer Science 2025-09-03 Vesa Kuikka , Lauri Pykälä , Tuomas Takko , Kimmo Kaski

The emerging field at the intersection of quantitative biology, network modeling, and control theory has enjoyed significant progress in recent years. This Special Issue brings together a selection of papers on complementary approaches to…

Molecular Networks · Quantitative Biology 2018-07-10 Reka Albert , John Baillieul , Adilson E. Motter

Dynamic networks models describe a growing number of important scientific processes, from cell biology and epidemiology to sociology and finance. There are many aspects of dynamical networks that require statistical considerations. In this…

Methodology · Statistics 2012-05-15 E. C. Wit , A. Abbruzzo

Transcriptomic data is a treasure-trove in modern molecular biology, as it offers a comprehensive viewpoint into the intricate nuances of gene expression dynamics underlying biological systems. This genetic information must be utilised to…

Molecular Networks · Quantitative Biology 2023-12-13 Vikram Singh , Vikram Singh

Probabilistic graphical models are a fundamental tool in probabilistic modeling, machine learning and artificial intelligence. They allow us to integrate in a natural way expert knowledge, physical modeling, heterogeneous and correlated…

Machine Learning · Statistics 2021-07-20 Panagiota Birmpa , Jinchao Feng , Markos A. Katsoulakis , Luc Rey-Bellet

Temporal networks have been increasingly used to model a diversity of systems that evolve in time; for example human contact structures over which dynamic processes such as epidemics take place. A fundamental aspect of real-life networks is…

Physics and Society · Physics 2017-11-08 Luis E C Rocha , Naoki Masuda , Petter Holme

We explore pseudometrics for directed graphs in order to better understand their topological properties. The directed flag complex associated to a directed graph provides a useful bridge between network science and topology. Indeed, it has…

Algebraic Topology · Mathematics 2021-07-26 Ana Lucia Garcia-Pulido , Kathryn Hess , Jane Tan , Katharine Turner , Bei Wang , Naya Yerolemou

Adaptive networks model social, physical, technical, or biological systems as attributed graphs evolving at the level of both their topology and data. They are naturally described by graph transformation, but the majority of authors take an…

Discrete Mathematics · Computer Science 2021-12-22 Nicolas Behr , Bello Shehu Bello , Sebastian Ehmes , Reiko Heckel