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We study the effect of intrinsic noise on the thermodynamic balance of complex chemical networks subtending cellular metabolism and gene regulation. A topological network property called deficiency, known to determine the possibility of…

Molecular Networks · Quantitative Biology 2015-11-12 Matteo Polettini , Artur Wachtel , Massimiliano Esposito

The regulatory mechanisms driving progression of the yeast cell cycle appears to be comprised of an interacting network of transcription factors (TFs), cyclin-dependent kinases (CDK) and ubiquitin ligases. From a systems perspective the…

Dynamical Systems · Mathematics 2023-02-28 Julian Fox , Breschine Cummins , Robert C. Moseley , Marcio Gameiro , Steven B. Haase

We study how the dynamics of a class of discrete dynamical system models for neuronal networks depends on the connectivity of the network. Specifically, we assume that the network is an Erd\H{o}s-R\'{enyi} random graph and analytically…

Dynamical Systems · Mathematics 2014-04-23 Winfried Just , Sungwoo Ahn

The capacity of cells and organisms to respond to challenging conditions in a repeatable manner is limited by a finite repertoire of pre-evolved adaptive responses. Beyond this capacity, cells can use exploratory dynamics to cope with a…

Molecular Networks · Quantitative Biology 2017-07-05 Hallel I. Schreier , Yoav Soen , Naama Brenner

The major biochemical networks of the living cell, the network of interacting genes and the network of biochemical reactions, are highly interdependent, however, they have been studied mostly as separate systems so far. In the last years an…

Molecular Networks · Quantitative Biology 2017-11-01 David F. Klosik , Anne Grimbs , Stefan Bornholdt , Marc-Thorsten Hütt

Large-scale white matter pathways crisscrossing the cortex create a complex pattern of connectivity that underlies human cognitive function. Generative mechanisms for this architecture have been difficult to identify in part because little…

Neurons and Cognition · Quantitative Biology 2015-06-16 Florian Klimm , Danielle S. Bassett , Jean M. Carlson , Peter J. Mucha

We propose a simple adaptive-network model describing recent swarming experiments. Exploiting an analogy with human decision making, we capture the dynamics of the model by a low-dimensional system of equations permitting analytical…

Disordered Systems and Neural Networks · Physics 2011-07-15 Cristián Huepe , Gerd Zschaler , Anne-Ly Do , Thilo Gross

The importance of structured, complex connectivity patterns found in several real-world systems is to a great extent related to their respective effects in constraining and even defining the respective dynamics. Yet, while complex networks…

Tissues and Organs · Quantitative Biology 2008-05-16 Matheus P. Viana , Bruno A. N. Travencolo , E. Tanck , Luciano da F. Costa

In this work we investigate time varying networks with complex dynamics at the nodes. We consider two scenarios of network change in an interval of time: first, we have the case where each link can change with probability pt, i.e. the…

Adaptation and Self-Organizing Systems · Physics 2014-04-14 Ankit Kumar , Vidit Agrawal , Sudeshna Sinha

A computer model is described which is used to assess the dynamical complexity of a class of networks of spiking neurons with small-world properties. Networks are constructed by forming an initially segregated set of highly intra-connected…

Biological Physics · Physics 2009-11-13 Murray Shanahan

Inferring topological characteristics of complex networks from observed data is critical to understand the dynamical behavior of networked systems, ranging from the Internet and the World Wide Web to biological networks and social networks.…

Multiagent Systems · Computer Science 2020-05-13 Chunheng Jiang , Jianxi Gao , Malik Magdon-Ismail

Interactions between neighboring cells are essential for generating or refining patterns in a number of biological systems. We propose a discrete filtering approach to predict how networks of cells modulate spatially varying input signals…

Tissues and Organs · Quantitative Biology 2019-02-14 Melinda Liu Perkins , Murat Arcak

We investigate the propagation of random fluctuations through biochemical networks in which the concentrations of species are large enough so that the unperturbed problem is well-described by ordinary differential equation. We characterize…

Probability · Mathematics 2007-05-23 David Anderson , Jonathan Mattingly , H. Frederik Nijhout , Michael Reed

The network paradigm is increasingly used to describe the dynamics of complex systems. Here we review the current results and propose future development areas in the assessment of perturbation waves, i.e. propagating structural changes in…

Molecular Networks · Quantitative Biology 2009-04-23 Miklos A. Antal , Csaba Bode , Peter Csermely

Networks are fundamental for our understanding of complex systems. Interactions between individual nodes in networks generate network motifs - small recurrent patterns that can be considered the network's building-block components,…

Dynamical Systems · Mathematics 2022-09-14 Miri Adler , Ruslan Medzhitov

The interest in dynamic processes on networks is steadily rising in recent years. In this paper, we consider the $(\alpha,\beta)$-Thresholded Network Dynamics ($(\alpha,\beta)$-Dynamics), where $\alpha\leq \beta$, in which only structural…

Distributed, Parallel, and Cluster Computing · Computer Science 2021-06-23 Evangelos Kipouridis , Paul G. Spirakis , Kostas Tsichlas

The deterministic dynamics of randomly connected neural networks are studied, where a state of binary neurons evolves according to a discreet-time synchronous update rule. We give a theoretical support that the overlap of systems' states…

Statistical Mechanics · Physics 2015-03-10 Taro Toyoizumi , Haiping Huang

Turing instability in activator-inhibitor systems provides a paradigm of nonequilibrium pattern formation; it has been extensively investigated for biological and chemical processes. Turing pattern formation should furthermore be possible…

Adaptation and Self-Organizing Systems · Physics 2010-05-13 Hiroya Nakao , Alexander S. Mikhailov

We investigate urban street networks as a whole within the frameworks of information physics and statistical physics. Urban street networks are envisaged as evolving social systems subject to a Boltzmann-mesoscopic entropy conservation. For…

Physics and Society · Physics 2019-07-18 Jerome Benoit , Saif Eddin Jabari

Attractors of dynamical systems may be networks in phase space that can be heteroclinic (where there are dynamical connections between simple invariant sets) or excitable (where a perturbation threshold needs to be crossed to a dynamical…

Adaptation and Self-Organizing Systems · Physics 2018-04-24 Peter Ashwin , Claire Postlethwaite