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A fundamental problem in neuroscience is to understand how sequences of action potentials ("spikes") encode information about sensory signals and motor outputs. Although traditional theories of neural coding assume that information is…

Neurons and Cognition · Quantitative Biology 2022-10-12 Kyle H. Srivastava , Caroline M. Holmes , Michiel Vellema , Andrea Pack , Coen P. H. Elemans , Ilya Nemenman , Samuel J. Sober

The problem of neural coding is to understand how sequences of action potentials (spikes) are related to sensory stimuli, motor outputs, or (ultimately) thoughts and intentions. One clear question is whether the same coding rules are used…

The nervous system represents time-dependent signals in sequences of discrete action potentials or spikes, all spikes are identical so that information is carried only in the spike arrival times. We show how to quantify this information, in…

Condensed Matter · Physics 2008-02-03 S. P. Strong , Roland Koberle , Rob R. de Ruyter van Steveninck , William Bialek

Understanding a neural code requires knowledge both of the elementary symbols that transmit information and of the algorithm for translating these symbols into sensory signals or motor actions. We show that these questions can be separated:…

Biological Physics · Physics 2007-05-23 N. Brenner , S. P. Strong , R. Koberle , W. Bialek , R. de Ruyter van Steveninck

Sensory systems take continuously varying stimuli as their input and encode features relevant for the organism's survival into a sequence of action potentials - spike trains. The full dynamic range of complex dynamical inputs has to be…

Neurons and Cognition · Quantitative Biology 2011-03-03 Ingrid M. Esteves , Nelson M. Fernandes , Roland Köberle

Why do neurons communicate through spikes? By definition, spikes are all-or-none neural events which occur at continuous times. In other words, spikes are on one side binary, existing or not without further details, and on the other can…

Neurons and Cognition · Quantitative Biology 2024-04-12 Antoine Grimaldi , Amélie Gruel , Camille Besnainou , Jean-Nicolas Jérémie , Jean Martinet , Laurent U Perrinet

Neural coding is a field of study that concerns how sensory information is represented in the brain by networks of neurons. The link between external stimulus and neural response can be studied from two parallel points of view. The first,…

Neurons and Cognition · Quantitative Biology 2012-03-07 Shinsuke Koyama

In nature, animals encounter high dimensional sensory stimuli that have complex statistical and dynamical structure. Attempts to study the neural coding of these natural signals face challenges both in the selection of the signal ensemble…

Biological Physics · Physics 2007-05-23 Brian D. Wright , Kamal Sen , William Bialek , Allison J. Doupe

We study a wide field motion sensitive neuron in the visual system of the blowfly {\em Calliphora vicina}. By rotating the fly on a stepper motor outside in a wooded area, and along an angular motion trajectory representative of natural…

Biological Physics · Physics 2007-05-23 G. D. Lewen , W. Bialek , R. R. de Ruyter van Steveninck

Neurons communicate with downstream systems via sparse and incredibly brief electrical pulses, or spikes. Using these events, they control various targets such as neuromuscular units, neurosecretory systems, and other neurons in connected…

Neurons and Cognition · Quantitative Biology 2026-03-17 Paolo Agliati , André Urbano , Pablo Lanillos , Nasir Ahmad , Marcel van Gerven , Sander Keemink

Studies of motor control have almost universally examined firing rates to investigate how the brain shapes behavior. In principle, however, neurons could encode information through the precise temporal patterning of their spike trains as…

Neurons and Cognition · Quantitative Biology 2014-04-15 Claire Tang , Diala Chehayeb , Kyle Srivastava , Ilya Nemenman , Samuel Sober

Neural decoding may be formulated as dynamic state estimation (filtering) based on point process observations, a generally intractable problem. Numerical sampling techniques are often practically useful for the decoding of real neural data.…

Neurons and Cognition · Quantitative Biology 2019-01-15 Yuval Harel , Ron Meir , Manfred Opper

We consider the information transmission problem in neurons and its possible implications for learning in neural networks. Our approach is based on recent developments in statistical physics and complexity science. Combining sensory…

Neurons and Cognition · Quantitative Biology 2025-09-30 Siddharth Kackar

A good understanding of how neurons use electrical pulses (i.e, spikes) to encode the signal information remains elusive. Analyzing spike sequences generated by individual neurons and by two coupled neurons (using the stochastic…

Neurons and Cognition · Quantitative Biology 2019-10-23 Maria Masoliver , Cristina Masoller

A key question in neuroscience is at which level functional meaning emerges from biophysical phenomena. In most vertebrate systems, precise functions are assigned at the level of neural populations, while single-neurons are deemed…

Neurons and Cognition · Quantitative Biology 2017-03-17 Wieland Brendel , Ralph Bourdoukan , Pietro Vertechi , Christian K. Machens , Sophie Denéve

It has long been debated whether information in the brain is coded at the rate of neuronal spiking or at the precise timing of single spikes. Although this issue is essential to the understanding of neural signal processing, it is not…

Neurons and Cognition · Quantitative Biology 2014-02-17 Yasuhiro Mochizuk , Shigeru Shinomoto

We construct a model that predicts the statistical properties of spike trains generated by a sensory neuron. The model describes the combined effects of the neuron's intrinsic properties, the noise in the surrounding, and the external…

Biological Physics · Physics 2009-10-31 N. Brenner , O. Agam , W. Bialek , R. de Ruyter van Steveninck

While spike timing has been shown to carry detailed stimulus information at the sensory periphery, its possible role in network computation is less clear. Most models of computation by neural networks are based on population firing rates.…

Neurons and Cognition · Quantitative Biology 2015-07-17 Michael A. Schwemmer , Adrienne L. Fairhall , Sophie Denéve , Eric T. Shea-Brown

Neural coding is one of the central questions in systems neuroscience for understanding how the brain processes stimulus from the environment, moreover, it is also a cornerstone for designing algorithms of brain-machine interface, where…

Neurons and Cognition · Quantitative Biology 2020-01-29 Yichen Zhang , Shanshan Jia , Yajing Zheng , Zhaofei Yu , Yonghong Tian , Siwei Ma , Tiejun Huang , Jian K. Liu

The relationship between a neuron's complex inputs and its spiking output defines the neuron's coding strategy. This is frequently and effectively modeled phenomenologically by one or more linear filters that extract the components of the…

Neurons and Cognition · Quantitative Biology 2011-11-02 Michael Famulare , Adrienne L. Fairhall
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