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200 papers

Multicellular systems play a key role in bioprocess and biomedical engineering. Cell ensembles encountered in these setups show phenotypic variability like size and biochemical composition. As this variability may result in undesired…

Systems and Control · Computer Science 2018-07-16 Armin Küper , Robert Dürr , Steffen Waldherr

We introduce and analyze several aspects of a new model for cell differentiation. It assumes that differentiation of progenitor cells is a continuous process. From the mathematical point of view, it is based on partial differential…

Analysis of PDEs · Mathematics 2013-01-21 Marie Doumic , Anna Marciniak-Czochra , Benoit Perthame , Jorge P. Zubelli

The survival of natural populations may be greatly affected by environmental conditions that vary in space and time. We look at a population residing in two locations (patches) coupled by migration, in which the local conditions fluctuate…

Statistical Mechanics · Physics 2021-08-11 Tal Agranov , Guy Bunin

Predictive modeling of the evolutionary dynamics of cancer is a challenge issue in computational cancer biology. In this paper, we propose a general mathematical model framework for the evolutionary dynamics of cancer with plasticity and…

Cell Behavior · Quantitative Biology 2020-01-10 Jinzhi Lei

The two-species population dynamics model is the simplest paradigm of interspecies interaction. Here, we include intraspecific competition to the Lotka-Volterra model and solve it analytically. Despite being simple and thoroughly studied,…

Populations and Evolution · Quantitative Biology 2015-03-17 Brenno Caetano Troca Cabella , Alexandre Souto Martinez , Fabiano Ribeiro

This article studies the quasi-stationary behaviour of population processes with unbounded absorption rate, including one-dimensional birth and death processes with catastrophes and multi-dimensional birth and death processes, modeling…

Probability · Mathematics 2016-11-10 Nicolas Champagnat , Denis Villemonais

Many models of population dynamics are formulated as deterministic iterated maps although real populations are stochastic. This is justifiable in the limit of large population sizes, as the stochastic fluctuations are negligible then.…

Populations and Evolution · Quantitative Biology 2025-09-16 Snehal M. Shekatkar

Real-world optimisation problems are often dynamic. Previously good solutions must be updated or replaced due to changes in objectives and constraints. It is often claimed that evolutionary algorithms are particularly suitable for dynamic…

Neural and Evolutionary Computing · Computer Science 2016-07-13 Duc-Cuong Dang , Thomas Jansen , Per Kristian Lehre

A simple weakly frequency dependent model for the dynamics of a population with a finite number of types is proposed, based upon an advantage of being rare. In the infinite population limit, this model gives rise to a non-smooth dynamical…

Populations and Evolution · Quantitative Biology 2007-05-23 Michael Baake , Uwe Grimm , Harald Jockusch

Game theoretic tools are utilized to analyze a one-locus continuous selection model of sex-specific meiotic drive by considering nonequivalence of the viabilities of reciprocal heterozygotes that might be noticed at an imprinted locus. The…

Populations and Evolution · Quantitative Biology 2015-12-07 Bijan Sarkar

Recently we have introduced a simplified model of ecosystem assembly (Capitan et al., 2009) for which we are able to map out all assembly pathways generated by external invasions in an exact manner. In this paper we provide a deeper…

Populations and Evolution · Quantitative Biology 2015-02-18 Jose A. Capitan , Jose A. Cuesta

Multispecies ecosystems modelled by generalized Lotka-Volterra equations exhibit stationary population abundances, where large number of species often coexist. Understanding the precise conditions under which this is at all feasible and…

Populations and Evolution · Quantitative Biology 2026-05-19 Philippe Jacquod

We study the multi-species replicator model with linear fitness and random fitness matrices of various classes. By means of numerical resolution of the replicator equations, we determine the survival probability of a species in terms of its…

Adaptation and Self-Organizing Systems · Physics 2007-05-23 Sebastian Bouzat , Damian Zanette

Microbiome-based stratification of healthy individuals into compositional categories, referred to as "community types", holds promise for drastically improving personalized medicine. Despite this potential, the existence of community types…

Quantitative Methods · Quantitative Biology 2016-04-27 Travis E. Gibson , Amir Bashan , Hong-Tai Cao , Scott T. Weiss , Yang-Yu Liu

The question of whether biological populations survive or are eventually driven to extinction has long been examined using mathematical models. In this work we study population survival or extinction using a stochastic, discrete…

Populations and Evolution · Quantitative Biology 2021-09-15 Yifei Li , Stuart T. Johnston , Pascal R. Buenzli , Peter van Heijster , Matthew J. Simpson

This work proposes and analyzes a family of spatially inhomogeneous epidemic models. This is our first effort to use stochastic partial differential equations (SPDEs) to model epidemic dynamics with spatial variations and environmental…

Dynamical Systems · Mathematics 2020-01-01 Dang H Nguyen , Nhu N Nguyen , George Yin

After an introduction to the general topic of models for a given locus of a diploid population whose quadratic dynamics is determined by a fitness landscape, we consider more specifically the models that can be treated using genetic (or…

Populations and Evolution · Quantitative Biology 2016-07-08 Nicolas Grosjean , Thierry Huillet , Geneviève Rollet

We investigate the evolutionary dynamics of a population structured in phenotype, subjected to trait dependent selection with a linearly moving optimum and an asexual mode of reproduction. Our model consists of a non-local and non-linear…

Analysis of PDEs · Mathematics 2021-12-09 Raphaël Forien , Jimmy Garnier , Florian Patout

In this paper, we inspect well-known population genetics and social dynamics models. In these models, interacting individuals, while participating in a self-organizing process, give rise to the emergence of complex behaviors and patterns.…

Populations and Evolution · Quantitative Biology 2012-07-11 Sven Banisch , Tanya Araújo

The dynamics of two competing species in a finite size community is one of the most studied problems in population genetics and community ecology. Stochastic fluctuations lead, inevitably, to the extinction of one of the species, but the…

Populations and Evolution · Quantitative Biology 2016-11-30 Matan Danino , David A. Kessler , Nadav M. Shnerb