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Detecting changepoints in a time series of length $N$ entails evaluating up to $2^{N-1}$ possible changepoint models, making exhaustive enumeration computationally infeasible. Genetic algorithms (GAs) provide a stochastic way to identify…

Computation · Statistics 2025-09-30 Mo Li , QiQi Lu

Stan is an open-source probabilistic programing language, primarily designed to do Bayesian data analysis. Its main inference algorithm is an adaptive Hamiltonian Monte Carlo sampler, supported by state of the art gradient computation.…

Applications · Statistics 2022-03-29 Charles C. Margossian , Yi Zhang , William R. Gillespie

Recently, it has become feasible to generate large-scale, multi-tissue gene expression data, where expression profiles are obtained from multiple tissues or organs sampled from dozens to hundreds of individuals. When traditional clustering…

Quantitative Methods · Quantitative Biology 2021-10-29 Pau Erola , Johan LM Björkegren , Tom Michoel

In the last years, tens of thousands gene expression profiles for cells of several organisms have been monitored. Gene expression is a complex transcriptional process where mRNA molecules are translated into proteins, which control most of…

Biomolecules · Quantitative Biology 2009-11-11 T. Ochiai , J. C. Nacher , T. Akutsu

Theoretical analyses of stochastic search algorithms, albeit few, have always existed since these algorithms became popular. Starting in the nineties a systematic approach to analyse the performance of stochastic search heuristics has been…

Neural and Evolutionary Computing · Computer Science 2017-09-05 Per Kristian Lehre , Pietro S. Oliveto

In recent years, with the rapid proliferation of research publications in the field of Artificial Intelligence, it is becoming increasingly difficult for researchers to effectively keep up with all the latest research in one's own domains.…

Information Retrieval · Computer Science 2018-12-19 Jieli Zhou , Yuntao Zhou , Yi Xu

The Gaussian graphical model is a widely used tool for learning gene regulatory networks with high-dimensional gene expression data. Most existing methods for Gaussian graphical models assume that the data are homogeneous, i.e., all samples…

Methodology · Statistics 2018-05-08 Bochao Jia , Faming Liang

Software testing relates to the process of accessing the functionality of a program against some defined specifications. To ensure conformance, test engineers often generate a set of test cases to validate against the user requirements.…

Software Engineering · Computer Science 2017-02-16 Kamal Z. Zamli , Fakhrud Din , Graham Kendall , Bestoun S. Ahmed

While modern parallel computing systems offer high performance, utilizing these powerful computing resources to the highest possible extent demands advanced knowledge of various hardware architectures and parallel programming models.…

Distributed, Parallel, and Cluster Computing · Computer Science 2018-05-03 Suejb Memeti , Sabri Pllana , Alecio Binotto , Joanna Kolodziej , Ivona Brandic

Approximate Bayesian Computation has been successfully used in population genetics to bypass the calculation of the likelihood. These methods provide accurate estimates of the posterior distribution by comparing the observed dataset to a…

This paper presents capabilities of using genetic algorithms to find approximations of function extrema, which cannot be found using analytic ways. To enhance effectiveness of calculations, algorithm has been parallelized using OpenMP…

Artificial Intelligence · Computer Science 2013-03-19 Lukasz Swierczewski

A software for managing simulation jobs and results, named "OACIS", is presented. It controls a large number of simulation jobs executed in various remote servers, keeps these results in an organized way, and manages the analyses on these…

Computational Physics · Physics 2014-09-23 Yohsuke Murase , Takeshi Uchitane , Nobuyasu Ito

Gene set analysis, a popular approach for analysing high-throughput gene expression data, aims to identify sets of genes that show enriched expression patterns between two conditions. In addition to the multitude of methods available for…

Discovering causal genetic variants from large genetic association studies poses many difficult challenges. Assessing which genetic markers are involved in determining trait status is a computationally demanding task, especially in the…

Genomics · Quantitative Biology 2015-04-09 Andrew L. Beam , Alison Motsinger-Reif , Jon Doyle

This paper introduces an automated heuristic process able to achieve high accuracy when matching graphical user interface widgets across multiple versions of a target application. The proposed implementation is flexible as it allows full…

Software Engineering · Computer Science 2017-02-24 Arthur-Jozsef Molnar

Cartesian Genetic Programming (CGP) has previously shown capabilities in image processing tasks by evolving programs with a function set specialized for computer vision. A similar approach can be applied to Atari playing. Programs are…

Neural and Evolutionary Computing · Computer Science 2018-06-18 Dennis G Wilson , Sylvain Cussat-Blanc , Hervé Luga , Julian F Miller

The generation of artificial data based on existing observations, known as data augmentation, is a technique used in machine learning to improve model accuracy, generalisation, and to control overfitting. Augmentor is a software package,…

Computer Vision and Pattern Recognition · Computer Science 2017-08-18 Marcus D. Bloice , Christof Stocker , Andreas Holzinger

varstan is an \proglang{R} package for Bayesian analysis of time series models using \proglang{Stan}. The package offers a dynamic way to choose a model, define priors in a wide range of distributions, check model's fit, and forecast with…

Computation · Statistics 2020-05-22 Izhar Asael Alonzo Matamoros , Cristian Andres Cruz Torres

There have been extensive works dealing with genetic algorithms (GAs) for seeking optimal solutions of shop scheduling problems. Due to the NP hardness, the time cost is always heavy. With the development of high performance computing (HPC)…

Distributed, Parallel, and Cluster Computing · Computer Science 2019-04-09 Jia Luo , Didier El Baz

Motivation: Modelling methods that find structure in data are necessary with the current large volumes of genomic data, and there have been various efforts to find subsets of genes exhibiting consistent patterns over subsets of treatments.…

Machine Learning · Computer Science 2016-09-15 Kerstin Bunte , Eemeli Leppäaho , Inka Saarinen , Samuel Kaski