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We present a sequence-based probabilistic formalism that directly addresses co-operative effects in networks of interacting positions in proteins, providing significantly improved contact prediction, as well as accurate quantitative…

Quantitative Methods · Quantitative Biology 2012-07-12 Alan Lapedes , Bertrand Giraud , Christopher Jarzynski

A general theoretical framework is developed using free energy functional methods to understand the effects of heterogeneity in the folding of a well-designed protein. Native energetic heterogeneity arising from non-uniformity in native…

Disordered Systems and Neural Networks · Physics 2007-05-23 Steven S. Plotkin , Jose N. Onuchic

The bilayer Hubbard model with an intra-layer hopping $t$ and an inter-layer hopping $t_\perp$ provides an interesting testing ground for several aspects of what has been called unconventional superconductivity. One can study the type of…

Superconductivity · Physics 2011-07-20 T. A. Maier , D. J. Scalapino

Networks of disparate phenomena-- be it the global ecology, human social institutions, within the human brain, or in micro-scale protein interactions-- exhibit broadly consistent architectural features. To explain this, we propose a new…

Physics and Society · Physics 2021-01-26 Keith M. Smith

As proteins typically have charges of around 10, they will interact strongly with charged surfaces. We calculate the electrostatic contribution to the interaction of crystals of protein with charged surfaces. The surfaces repel like-charged…

Soft Condensed Matter · Physics 2009-11-10 Richard P. Sear

Modeling of polymer chains has received a lot of attention in mathematics. In fact, probabilistic models that naturally arise in statistical mechanics have been widely studied by mathematicians for the very challenging and novel problems…

Probability · Mathematics 2007-05-23 Francesco Caravenna

Adaptive humoral immunity, from the physical perspective, can be regarded as the self-organization of the binding energy landscape of antibodies. In biological terms, the humoral immune system evolves and adapts its repertoire of antigen…

Other Quantitative Biology · Quantitative Biology 2025-09-15 Jozsef Prechl

The planar-diagrammatic technique of large-$N$ random matrices is extended to evaluate averages over the circular ensemble of unitary matrices. It is then applied to study transport through a disordered metallic ``grain'', attached through…

Condensed Matter · Physics 2009-10-28 N. Argaman , A. Zee

We study a heteropolymer model with random contact interactions introduced some time ago as a simplified model for proteins. The model consists of self-avoiding walks on the simple cubic lattice, with contact interactions between nearest…

Soft Condensed Matter · Physics 2009-10-31 Ugo Bastolla , Peter Grassberger

A model of interacting one--dimensional fermions confined to a harmonic trap is proposed. The model is treated analytically to all orders of the coupling constant by a method analogous to that used for the Luttinger model. As a first…

Quantum Physics · Physics 2009-11-06 W. Wonneberger

Successive whole genome duplications have recently been firmly established in all major eukaryote kingdoms. It is not clear, however, how such dramatic evolutionary process has contributed to shape the large scale topology of…

Molecular Networks · Quantitative Biology 2007-05-23 K. Evlampiev , H. Isambert

Unveiling individuals' preferences for connecting with similar others (choice homophily) beyond the structural factors determining the pool of opportunities, is a challenging task. Here, we introduce a robust methodology for quantifying and…

Physics and Society · Physics 2024-01-25 Sina Sajjadi , Samuel Martin-Gutierrez , Fariba Karimi

We argue that an ensemble of backgrounds best understands hydrodynamic dispersion relations in a medium with few degrees of freedom and is therefore subject to strong thermal fluctuations. In the linearized regime, dispersion relations…

High Energy Physics - Theory · Physics 2024-08-23 Farid Taghinavaz , Giorgio Torrieri

We investigate the model of "reversible ratchet" with interacting particles, introduced by us earlier [Europhys. Lett. 84, 50009 (2008)]. We further clarify the effect of efficiency enhancement due to interaction and show that it is of…

Statistical Mechanics · Physics 2015-03-19 Frantisek Slanina

The thermoelectric response of molecular junctions exhibits large fluctuations, as observed in recent experiments [e.g. Malen J. A. {\sl et al.}, Nano Lett. {\bf 10}, 3406 (2009)]. These were attributed to fluctuations in the energy…

Mesoscale and Nanoscale Physics · Physics 2015-06-12 Yonatan Dubi

Proteins are minimally frustrated polymers. However, for realistic protein models non-native interactions must be taken into account. In this paper we analyze the effect of non-native interactions on the folding rate and on the folding free…

Biomolecules · Quantitative Biology 2007-05-23 C. Clementi , S. S. Plotkin

Heterogeneity is classified in five categories---topologic, geometric, kinematic, static, and constitutive---and the first four categories are investigated in a numerical DEM simulation of biaxial compression. The simulation experiments…

Soft Condensed Matter · Physics 2019-01-23 Matthew R. Kuhn

One of the most interesting phenomena in the soft-matter realm consists in the spontaneous formation of super-molecular structures (microphases) in condition of thermodynamic equilibrium. A simple mechanism responsible for this…

Soft Condensed Matter · Physics 2017-08-23 A. Imperio , D. Pini , L. Reatto

The adhesive contact between elastic solids with randomly rough, self affine fractal surfaces is studied by molecular dynamics (MD) simulations. The interfacial binding energy obtained from the simulations of nominally flat and curved…

Soft Condensed Matter · Physics 2011-12-23 N. Mulakaluri , B. N. J. Persson

We present new method for studying the equilibrium properties of interacting fluids in an arbitrary external filed. The method is valid in any dimension and it yields an exact results in one dimension. Using this approach, we derive a…

Soft Condensed Matter · Physics 2017-02-17 Benaoumeur Bakhti