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Complexes of physically interacting proteins constitute fundamental functional units responsible for driving biological processes within cells. A faithful reconstruction of the entire set of complexes is therefore essential to understand…

Molecular Networks · Quantitative Biology 2015-05-21 Sriganesh Srihari , Chern Han Yong , Ashwini Patil , Limsoon Wong

The identification of essential proteins can help in understanding the minimum requirements for cell survival and development. Network-based centrality approaches are commonly used to identify essential proteins from protein-protein…

Computational Engineering, Finance, and Science · Computer Science 2023-11-13 Li Pan , Haoyue Wang , Jing Sun , Bin Li , Bo Yang , Wenbin Li

Summary: The ModuLand plug-in provides Cytoscape users an algorithm for determining extensively overlapping network modules. Moreover, it identifies several hierarchical layers of modules, where meta-nodes of the higher hierarchical layer…

Computational Physics · Physics 2012-12-04 Mate Szalay-Beko , Robin Palotai , Balazs Szappanos , Istvan A. Kovacs , Balazs Papp , Peter Csermely

Compound graphs are networks in which vertices can be grouped into larger subsets, with these subsets capable of further grouping, resulting in a nesting that can be many levels deep. In several applications, including biological workflows,…

Human-Computer Interaction · Computer Science 2024-08-09 Chang Han , Justin Lieffers , Clayton Morrison , Katherine E. Isaacs

Many networks in real-life typically contain parts in which some nodes are more highly connected to each other than the other nodes of the network. The collection of such nodes are usually called clusters, communities, cohesive groups or…

Distributed, Parallel, and Cluster Computing · Computer Science 2008-06-20 Xiahong Lin , Lin Gao , Kefei Chen , David K. Y. Chiu

We present a novel method for detecting communities in bipartite networks. Based on an extension of the $k$-clique community detection algorithm, we demonstrate how modular structure in bipartite networks presents itself as overlapping…

Data Analysis, Statistics and Probability · Physics 2008-07-22 Sune Lehmann , Martin Schwartz , Lars Kai Hansen

Many complex networks display a mesoscopic structure with groups of nodes sharing many links with the other nodes in their group and comparatively few with nodes of different groups. This feature is known as community structure and encodes…

Physics and Society · Physics 2009-07-31 Andrea Lancichinetti , Santo Fortunato

Community structure is a typical property of many real-world networks, and has become a key to understand the dynamics of the networked systems. In these networks most nodes apparently lie in a community while there often exists a few nodes…

Social and Information Networks · Computer Science 2017-12-07 Zhan Weihua , Chen Huahui , Guan Jihong , Jin Guang

Much effort has gone into understanding the modular nature of complex networks. Communities, also known as clusters or modules, are typically considered to be densely interconnected groups of nodes that are only sparsely connected to other…

Physics and Society · Physics 2012-06-26 James P. Bagrow

Community detection in social graphs has attracted researchers' interest for a long time. With the widespread of social networks on the Internet it has recently become an important research domain. Most contributions focus upon the…

Social and Information Networks · Computer Science 2014-02-26 Michel Crampes , Michel Plantié

Overlapping communities are key characteristics of the structure and function analysis of complex networks. Shared or overlapping nodes within overlapping communities can form either subcommunities or act as intersections between larger…

Social and Information Networks · Computer Science 2025-12-19 Vesa Kuikka , Kosti Koistinen , Kimmo K Kaski

Complexes of physically interacting proteins are one of the fundamental functional units responsible for driving key biological mechanisms within the cell. Their identification is therefore necessary not only to understand complex formation…

Computational Engineering, Finance, and Science · Computer Science 2012-11-27 Sriganesh Srihari , Hon Wai Leong

Recent researches have discovered that rich interactions among entities in nature and society bring about complex networks with community structures. Although the investigation of the community structures has promoted the development of…

Physics and Society · Physics 2008-04-24 Nan Du , Bin Wu , Bai Wang , Yi Wang

This paper presents a new, parallel implementation of clustering and demonstrates its utility in greatly speeding up the process of identifying homologous proteins. Clustering is a technique to reduce the number of comparison needed to find…

Distributed, Parallel, and Cluster Computing · Computer Science 2019-08-29 Stuart Byma , Akash Dhasade , Adrian Altenhoff , Christophe Dessimoz , James R. Larus

Role discovery is the task of dividing the set of nodes on a graph into classes of structurally similar roles. Modern strategies for role discovery typically rely on graph embedding techniques, which are capable of recognising complex local…

Social and Information Networks · Computer Science 2022-06-08 Eoghan Cunningham , Derek Greene

Here we present ComPPI, a cellular compartment specific database of proteins and their interactions enabling an extensive, compartmentalized protein-protein interaction network analysis (http://ComPPI.LinkGroup.hu). ComPPI enables the user…

Molecular Networks · Quantitative Biology 2015-01-14 Daniel V. Veres , David M. Gyurko , Benedek Thaler , Kristof Z. Szalay , David Fazekas , Tamas Korcsmaros , Peter Csermely

Matrices are two-dimensional data structures allowing one to conceptually organize information. For example, adjacency matrices are useful to store the links of a network; correlation matrices are simple ways to arrange gene co-expression…

Disordered Systems and Neural Networks · Physics 2022-09-29 Flaviano Morone

Complex networks possess a rich, multi-scale structure reflecting the dynamical and functional organization of the systems they model. Often there is a need to analyze multiple networks simultaneously, to model a system by more than one…

Physics and Society · Physics 2012-11-29 Tom Michoel , Bruno Nachtergaele

Community detection, which focuses on clustering nodes or detecting communities in (mostly) a single network, is a problem of considerable practical interest and has received a great deal of attention in the research community. While being…

Machine Learning · Statistics 2017-11-07 Soumendu Sundar Mukherjee , Purnamrita Sarkar , Lizhen Lin

Identification of communities in complex networks has become an effective means to analysis of complex systems. It has broad applications in diverse areas such as social science, engineering, biology and medicine. Finding communities of…

Social and Information Networks · Computer Science 2013-09-19 Dongxiao He , Di Jin , Weixiong Zhang