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Aggregation of chemotactic bacteria under a unimodal distribution of chemical cues was investigated by Monte Carlo (MC) simulation based on a kinetic transport equation, which considers an internal adaptation dynamics as well as a finite…

Analysis of PDEs · Mathematics 2022-09-05 Shugo Yasuda

In eukaryotic cell chemotaxis, cells extend and retract transient actin-driven protrusions at their membrane that facilitate both the detection of external chemical gradients and directional movement via the formation of focal adhesions…

Cell Behavior · Quantitative Biology 2025-09-25 Samuel W. S. Johnson , Maddy Parsons , Ruth E. Baker , Philip K. Maini

As the closest unicellular relatives of animals, choanoflagellates serve as useful model organisms for understanding the evolution of animal multicellularity. An important factor in animal evolution was the increasing ocean oxygen levels in…

Soft Condensed Matter · Physics 2016-06-21 Julius B. Kirkegaard , Ambre Bouillant , Alan O. Marron , Kyriacos C. Leptos , Raymond E. Goldstein

Swimming bacteria detect chemical gradients by performing temporal comparisons of recent measurements of chemical concentration. These comparisons are described quantitatively by the chemotactic response function, which we expect to…

Cell Behavior · Quantitative Biology 2009-11-13 Damon A. Clark , Lars C. Grant

Living cells are capable of interacting with their environments in a variety of ways, including cell signalling, adhesion, and directed motion. These behaviours are often mediated by receptor molecules embedded in the cell membrane, which…

Biological Physics · Physics 2023-10-17 Hannah Sleath , Bortolo Mognetti , Yuval Elani , Lorenzo Di Michele

Colonies of bacteria grown on thin agar plate exhibit fractal patterns as a result of adaptation to their environments. The bacterial colony pattern formation is regulated crucially by chemotaxis, the movement of cells along a chemical…

Biological Physics · Physics 2013-05-24 Waipot Ngamsaad , Kannika Khompurngson

The ability of many living systems to actively self-propel underlies critical biomedical, environmental, and industrial processes. While such active transport is well-studied in uniform settings, environmental complexities such as geometric…

Biological Physics · Physics 2021-08-23 Alejandro Martínez-Calvo , Carolina Trenado-Yuste , Sujit S. Datta

In nature, microorganisms must often cope with hostile environmental conditions. To do so they have developed sophisticated cooperative behavior and intricate communication capabilities, such as: direct cell-cell physical interactions via…

Condensed Matter · Physics 2007-05-23 Eshel Ben-Jacob , Inon Cohen , Ido Golding , Yonathan Kozlovsky

Enzymes show two distinct transport behaviors in the presence of their substrates in solution. First, their diffusivity enhances with increasing substrate concentration. In addition, enzymes perform directional motion toward regions with…

Biological Physics · Physics 2018-11-06 Farzad Mohajerani , Xi Zhao , Ambika Somasundar , Darrell Velegol , Ayusman Sen

In this paper, we consider three non-linear kinetic partial differential equations that emerge in the modeling of motion of rod-shaped cells such as myxobacteria. This motion is characterized by nematic alignment with neighboring cells,…

Analysis of PDEs · Mathematics 2024-01-11 Patrick Murphy , Oleg Igoshin , Misha Perepelitsa , Ilya Timofeyev

The study of biological cells in terms of mesoscopic, nonequilibrium, nonlinear, stochastic dynamics of open chemical systems provides a paradigm for other complex, self-organizing systems with ultra-fast stochastic fluctuations, short-time…

Chemical Physics · Physics 2014-11-06 Hong Qian

Various microorganisms and some mammalian cells are able to swim in viscous fluids by performing nonreciprocal body deformations, such as rotating attached flagella or by distorting their entire body. In order to perform chemotaxis, i.e. to…

Biological Physics · Physics 2021-05-06 Benedikt Hartl , Maximilian Hübl , Gerhard Kahl , Andreas Zöttl

Chemotaxis is typically modeled in the context of cellular motion towards a static, exogenous source of chemoattractant. Here, we propose a time-dependent mechanism of chemotaxis in which a self-propelled particle ({\it e.g.}, a cell)…

Cell Behavior · Quantitative Biology 2026-05-12 Sarah A. Nowak , Buddhapriya Chakrabarti , Tom Chou , Ajay Gopinathan

We perform stability analysis of a kinetic bacterial chemotaxis model of bacterial self-organization, assuming that bacteria respond sharply to chemical signals. The resulting discontinuous tumbling kernel represents the key challenge for…

Analysis of PDEs · Mathematics 2024-06-27 Vincent Calvez , Gianluca Favre , Franca Hoffmann

Collective motion of cells is common in many physiological processes, including tissue development, repair, and tumor formation. Recent experiments have shown that certain malignant cancer cells form clusters in a chemoattractant gradient,…

Biological Physics · Physics 2017-05-02 Katherine Copenhagen , Gema Malet-Engra , Weimiao Yu , Giorgio Scita , Nir Gov , Ajay Gopinathan

We show how the nonlinear interaction effects `volume filling' and `adhesion' can be incorporated into the fractional subdiffusive transport of cells and individual organisms. To this end, we use microscopic random walk models with…

Statistical Mechanics · Physics 2015-01-20 Peter Straka , Sergei Fedotov

Chemotaxis refers to the directed movement of cells in response to a chemical signal called chemoattractant. A crucial point in the mathematical modeling of chemotactic processes is the correct description of the chemotactic sensitivity and…

Analysis of PDEs · Mathematics 2015-01-08 Herbert Egger , Jan-Frederik Pietschmann , Matthias Schlottbom

In this paper the first equation within a class of well known chemotaxis systems is derived as a hydrodynamic limit from a stochastic interacting many particle system on the lattice. The cells are assumed to interact with attractive…

Probability · Mathematics 2018-04-26 Stefan Grosskinsky , Daniel Marahrens , Angela Stevens

Advances in synthetic biology allow us to engineer bacterial collectives with pre-specified characteristics. However, the behavior of these collectives is difficult to understand, as cellular growth and division as well as extra-cellular…

Cell Behavior · Quantitative Biology 2017-09-13 James J. Winkle , Oleg Igoshin , Matthew R. Bennett , Krešimir Josić , William Ott

We study mechanisms for wavenumber selection in a minimal model for run-and-tumble dynamics. We show that nonlinearity in tumbling rates induces the existence of a plethora of traveling- and standing-wave patterns, as well as a subtle…

Pattern Formation and Solitons · Physics 2017-02-14 Arnd Scheel , Angela Stevens