Related papers: Towards a Quantitative, Metabolic Theory for Mamma…
There are two contrasting explanations of sleep: as a proximate, essential physiological function or as an adaptive state of inactivity and these hypotheses remain widely debated. To investigate the adaptive significance of sleep, we…
Mammalian sleep is characterized by multiple alternations between episodes of rapid-eye-movement sleep (REMS) and non-REM sleep (NREMS). While the mechanisms governing the timing of these ultradian NREMS-REMS cycles remain poorly…
Study Objectives: Fetal sleep is a vital yet underexplored aspect of prenatal neurodevelopment. Its cyclic organization reflects the maturation of central neural circuits, and disturbances in these patterns may offer some of the earliest…
Three abilities - the ability to recognize sounds, the ability to visually recognize movement and the ability to keep an upright standing position - can function only with using precise measurements of the short time intervals. Other…
Sleep is commonly studied through neurochemical, evolutionary, and behavioral frameworks, typically emphasizing circadian rhythms and energy conservation. However, these approaches do not fully explain a deeper biophysical question: why…
Metabolism plays a crucial role in sleep regulation, yet its effects are challenging to track in real time. This study introduces a machine learning-based framework to analyze sleep patterns and identify how metabolic changes influence…
Sleep is essential for the maintenance of the brain and the body, yet many features of sleep are poorly understood and mathematical models are an important tool for probing proposed biological mechanisms. The most well-known mathematical…
Sleep is critical to leading a healthy lifestyle. Each day, most people go to sleep without any idea about how their night's rest is going to be. For an activity that humans spend around a third of their life doing, there is a surprising…
In this note, we present a hypothesis for the emergence of the phenomenon of sleep in organisms with sufficiently developed central nervous systems. We argue that sleep emerges because individual neurons must periodically enter a resting…
Human cognitive performance is critical to productivity, learning, and accident avoidance. Cognitive performance varies throughout each day and is in part driven by intrinsic, near 24-hour circadian rhythms. Prior research on the impact of…
According to the recently discovered 'Law of Urination', mammals, ranging in size from mice to elephants, take, on the average, 21s to urinate. We attempt to gain insights into the physical processes responsible for this uniformity using…
Allometric scaling is one of the most pervasive laws in biology. Its origin, however, is still a matter of dispute. Recent studies have established that maximum metabolic rate scales with an exponent larger than that found for basal…
Human sleep is cyclical with a period of approximately 90 minutes, implying long temporal dependency in the sleep data. Yet, exploring this long-term dependency when developing sleep staging models has remained untouched. In this work, we…
This paper develops a highly simplified model with which to analyze the phenomenon of sleep. Motivated by Crick's suggestion that sleep is the brain's way of ``taking out the trash,'' a suggestion that is supported by emerging evidence, we…
Dormancy is a widespread adaptive strategy that enables populations to persist in fluctuating environments, yet how its benefits depend on the temporal structure of environmental variability remains unclear. We examine how dormancy…
We examine the scaling law $B \propto M^{\alpha}$ which connects organismal metabolic rate $B$ with organismal mass $M$, where $\alpha$ is commonly held to be 3/4. Since simple dimensional analysis suggests $\alpha=2/3$, we consider this to…
Sleep is considered to play an essential role in memory reorganization. Despite its importance, classical theoretical models did not focus on some sleep characteristics. Here, we review recent theoretical approaches investigating their…
During mammalian development the cerebral metabolic rate correlates qualitatively with synaptogenesis, and both often exhibit bimodal temporal profiles. Despite these non-monotonic dependencies, it is found based on empirical data for…
A number of studies have concluded that dreaming is mostly caused by randomly arriving internal signals because "dream contents are random impulses", and argued that dream sleep is unlikely to play an important part in our intellectual…
Previous research has shown a clear relationship between sleep and memory, examining the impact of sleep deprivation on key cognitive processes over very short durations or in special populations. Here, we show, in a longitudinal 16 week…