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Protein-protein interaction (PPI) modeling has been widely studied as a binary or multi-label classification task. While emerging multimodal large language models (LLMs) can now describe single proteins, they remain unable to generate…

Computational Engineering, Finance, and Science · Computer Science 2026-05-12 Xiao Fei , Sarah Almeida Carneiro , Yang Zhang , Lawrence P. Petalidis , Achilleas Tsortos , Costas Bouyioukos , Michalis Vazirgiannis

Extensive studies have been done to understand the principles behind architectures of real networks. Recently, evidences for hierarchical organization in many real networks have also been reported. Here, we present a new hierarchical model…

Other Condensed Matter · Physics 2007-05-23 J. C. Nacher , N. Ueda , M. Kanehisa , T. Akutsu

Empirical results show that spatial factors such as distance, population density and communication range affect our social activities, also reflected by the development of ties in social networks. This motivates the need for social network…

Physics and Society · Physics 2020-03-04 Dong Liu , Viktoria Fodor , Lars K. Rasmussen

We study the correlation between the codon usage bias of genetic sequences and the network features of protein-protein interaction (PPI) in bacterial species. We use PCA techniques in the space of codon bias indices to show that genes with…

Genomics · Quantitative Biology 2021-02-23 Maddalena Dilucca , Giulio Cimini , Sergio Forcelloni , Andrea Giansanti

A growing family of random graphs is called robust if it retains a giant component after percolation with arbitrary positive retention probability. We study robustness for graphs, in which new vertices are given a spatial position on the…

Probability · Mathematics 2015-04-08 Emmanuel Jacob , Peter Morters

Network theorists have developed methods to characterize the complex interactions in natural phenomena. The structure of the network of interactions between proteins is important in the field of proteomics, and has been subject to intensive…

Molecular Networks · Quantitative Biology 2016-09-07 Allan A. Zea , Antonio Rueda-Toicen

How are people linked in a highly connected society? Since in many networks a power-law (scale-free) node-degree distribution can be observed, power-law might be seen as a universal characteristics of networks. But this study of…

Physics and Society · Physics 2023-06-22 Matthias Scholz

It has been well-known that many real networks are scale-free (SF) but extremely vulnerable against attacks. We investigate the robustness of connectivity and the lengths of the shortest loops in randomized SF networks with realistic…

Social and Information Networks · Computer Science 2026-02-03 Yingzhou Mou , Yukio Hayashi

In this paper we theoretically and empirically study the degree and connectivity of the Internet's scale-free topology at the autonomous system (AS) level. The basic features of the scale-free network have influence on the normalization…

Networking and Internet Architecture · Computer Science 2011-06-03 Lianming Zhang , Xiaoheng Deng , Jianping Yu , Xiangsheng Wu

Scale-free networks with moderate edge dependence experience a phase transition between ultrasmall and small world behaviour when the power law exponent passes the critical value of three. Moreover, there are laws of large numbers for the…

Probability · Mathematics 2017-05-05 Steffen Dereich , Christian Mönch , Peter Mörters

We define a statistical ensemble of non-degenerate graphs, i.e. graphs without multiple- and self-connections between nodes. The node degree distribution is arbitrary, but the nodes are assumed to be uncorrelated. This completes our earlier…

Statistical Mechanics · Physics 2009-11-07 Z. Burda , A. Krzywicki

We propose a model for growing networks based on a finite memory of the nodes. The model shows stylized features of real-world networks: power law distribution of degree, linear preferential attachment of new links and a negative…

Condensed Matter · Physics 2009-11-07 Konstantin Klemm , Victor M. Eguiluz

Proteins participating in a protein-protein interaction network can be grouped into homology classes following their common ancestry. Proteins added to the network correspond to genes added to the classes, so that the dynamics of the two…

Molecular Networks · Quantitative Biology 2013-05-30 Arianna Bottinelli , Bruno Bassetti , Marco Cosentino Lagomarsino , Marco Gherardi

The interactions between particles in particulate systems are organized in `force networks', mesoscale features that bridge between the particle scale and the scale of the system as a whole. While such networks are known to be crucial in…

We find that scale-free random networks are excellently modeled by a deterministic graph. This graph has a discrete degree distribution (degree is the number of connections of a vertex) which is characterized by a power-law with exponent…

Statistical Mechanics · Physics 2009-11-07 S. N. Dorogovtsev , A. V. Goltsev , J. F. F. Mendes

The classical approach to protein folding inspired by statistical mechanics avoids the high dimensional structure of the conformation space by using effective coordinates. Here we introduce a network approach to capture the statistical…

Biomolecules · Quantitative Biology 2007-05-23 Erzsebet Ravasz , S. Gnanakaran , Zoltan Toroczkai

Deep learning-based computational methods have achieved promising results in predicting protein-protein interactions (PPIs). However, existing benchmarks predominantly focus on isolated pairwise evaluations, overlooking a model's capability…

Machine Learning · Computer Science 2025-10-23 Xinzhe Zheng , Hao Du , Fanding Xu , Jinzhe Li , Zhiyuan Liu , Wenkang Wang , Tao Chen , Wanli Ouyang , Stan Z. Li , Yan Lu , Nanqing Dong , Yang Zhang

We present empirical evidence that land values are scale-free and introduce a network model that reproduces the observations. The network approach to urban modelling is based on the assumption that the market dynamics that generates land…

Disordered Systems and Neural Networks · Physics 2009-11-10 Claes Andersson , Alexander Hellervik , Kristian Lindgren , Anders Hagson , Jonas Tornberg

In this paper we provide numerical evidence of the richer behavior of the connectivity degrees in heterogeneous preferential attachment networks in comparison to their homogeneous counterparts. We analyze the degree distribution in the…

Other Condensed Matter · Physics 2009-11-13 A. Santiago , R. M. Benito

Random networks with complex topology are common in Nature, describing systems as diverse as the world wide web or social and business networks. Recently, it has been demonstrated that most large networks for which topological information…

Disordered Systems and Neural Networks · Physics 2016-08-31 Albert-Laszlo Barabasi , Reka Albert , Hawoong Jeong