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Quantification of information content and its temporal variation in intracellular calcium spike trains in neurons helps one understand functions such as memory, learning, and cognition. Such quantification could also reveal pathological…

Signal Processing · Electrical Eng. & Systems 2021-02-02 Sathish Ande , Srinivas Avasarala , Jayanth R Regatti , Neha Pandey , Sarpras Swain , Ajith Karunarathne , Lopamudra Giri , Soumya Jana

The highly irregular spiking activity of cortical neurons and behavioral variability suggest that the brain could operate in a fundamentally probabilistic way. Mimicking how the brain implements and learns probabilistic computation could be…

Neural and Evolutionary Computing · Computer Science 2024-04-23 Yang Qi , Zhichao Zhu , Yiming Wei , Lu Cao , Zhigang Wang , Jie Zhang , Wenlian Lu , Jianfeng Feng

Spike sorting is an essential process in neural recording, which identifies and separates electrical signals from individual neurons recorded by electrodes in the brain, enabling researchers to study how specific neurons communicate and…

Neurons and Cognition · Quantitative Biology 2025-12-23 Yimu Zhang , Dongqi Han , Yansen Wang , Zhenning Lv , Yu Gu , Dongsheng Li

We propose a novel backpropagation algorithm for training spiking neural networks (SNNs) that encodes information in the relative multiple spike timing of individual neurons without single-spike restrictions. The proposed algorithm inherits…

Neural and Evolutionary Computing · Computer Science 2026-05-15 Kakei Yamamoto , Yusuke Sakemi , Kazuyuki Aihara

Memristor-based Spiking Neural Networks (SNNs) with temporal spike encoding enable ultra-low-energy computation, making them ideal for battery-powered intelligent devices. This paper presents a circuit-level memristive spiking neural…

Emerging Technologies · Computer Science 2025-07-29 Santlal Prajapati , Susmita Sur-Kolay , Soumyadeep Dutta

Spike sorting is essential for extracting neuronal information from neural signals and understanding brain function. With the advent of high-density microelectrode arrays (HDMEAs), the challenges and opportunities in multi-channel spike…

Signal Processing · Electrical Eng. & Systems 2024-12-30 Yuntao Han , Shiwei Wang , Alister Hamilton

Spiking neural networks (SNNs) provide an energy-efficient solution by utilizing the spike-based and sparse nature of biological systems. Since the advent of Transformers, SNNs have struggled to compete with artificial networks on long…

Neural and Evolutionary Computing · Computer Science 2024-10-24 Yan Zhong , Ruoyu Zhao , Chao Wang , Qinghai Guo , Jianguo Zhang , Zhichao Lu , Luziwei Leng

A long tradition in theoretical neuroscience casts sensory processing in the brain as the process of inferring the maximally consistent interpretations of imperfect sensory input. Recently it has been shown that Gamma-band inhibition can…

Neurons and Cognition · Quantitative Biology 2017-09-04 Lorenz K. Muller , Giacomo Indiveri

Extracellular recordings with multi-electrode arrays is one of the basic tools of contemporary neuroscience. These recordings are mostly used to monitor the activities, understood as sequences of emitted action potentials, of many…

Computational Engineering, Finance, and Science · Computer Science 2014-12-22 Christophe Pouzat , Georgios Is. Detorakis

Restricted Boltzmann Machines and Deep Belief Networks have been successfully used in a wide variety of applications including image classification and speech recognition. Inference and learning in these algorithms uses a Markov Chain Monte…

Spiking neural networks (SNNs) are powerful mathematical models that integrate the biological details of neural systems, but their complexity often makes them computationally expensive and analytically untractable. The firing rate of an SNN…

Neurons and Cognition · Quantitative Biology 2025-05-15 Zhongyi Wang , Louis Tao , Zhuo-Cheng Xiao

There is an increasing demand to process streams of temporal data in energy-limited scenarios such as embedded devices, driven by the advancement and expansion of Internet of Things (IoT) and Cyber-Physical Systems (CPS). Spiking neural…

Neural and Evolutionary Computing · Computer Science 2020-07-08 Haowen Fang , Amar Shrestha , Qinru Qiu

Electrophysiological techniques have improved substantially over the past years to the point that neuroprosthetics applications are becoming viable. This evolution has been fuelled by the advancement of implantable microelectrode…

Emerging Technologies · Computer Science 2017-07-28 Isha Gupta , Alexantrou Serb , Ali Khiat , Maria Trapatseli , Themistoklis Prodromakis

Spikes can be easily detected inmostintracellular recordings as sharp peaks. However, insome experimental preparations,because of unipolar morphology or other characteristicsof the recorded neurons, the sizes of the spikes recorded from the…

Neurons and Cognition · Quantitative Biology 2021-11-23 Smith Gupta

This paper deals with the problem of inferring the signals and parameters that cause neural activity to occur. The ultimate challenge being to unveil brain's connectivity, here we focus on a microscopic vision of the problem, where single…

Computation · Statistics 2015-11-13 Pau Closas , Antoni Guillamon

Spike sorting is a fundamental preprocessing step for many neuroscience studies which rely on the analysis of spike trains. In this paper, we present two unsupervised spike sorting algorithms based on discriminative subspace learning. The…

Computer Vision and Pattern Recognition · Computer Science 2014-08-25 Mohammad Reza Keshtkaran , Zhi Yang

The Multi-Spike Tempotron (MST) is a powerful single spiking neuron model that can solve complex supervised classification tasks. While powerful, it is also internally complex, computationally expensive to evaluate, and not suitable for…

Neural and Evolutionary Computing · Computer Science 2020-03-09 Jakub Fil , Dominique Chu

We address the problem of identifying functional interactions among stochastic neurons with variable-length memory from their spiking activity. The neuronal network is modeled by a stochastic system of interacting point processes with…

Applications · Statistics 2025-07-01 Ricardo F. Ferreira , Matheus E. Pacola , Vitor G. Schiavone , Rodrigo F. O. Pena

Accurate statistical models of neural spike responses can characterize the information carried by neural populations. But the limited samples of spike counts during recording usually result in model overfitting. Besides, current models…

Quantitative Methods · Quantitative Biology 2021-06-17 Qi She , Xiaoli Wu , Beth Jelfs , Adam S. Charles , Rosa H. M. Chan

Background: Spike trains of multiple neurons can be analyzed following the summed population (SP) or the labeled line (LL) hypothesis. Responses to external stimuli are generated by a neuronal population as a whole or the individual neurons…

Neurons and Cognition · Quantitative Biology 2018-09-17 Eero Satuvuori , Mario Mulansky , Andreas Daffertshofer , Thomas Kreuz